UK Renal Registry 18th Annual Report: Chapter 4 Demography of Patients Receiving Renal Replacement Therapy in Paediatric Centres in the UK in 2014

Alexander J Hamilton, Fiona E M Braddon, Anna Casula, Carol D Inward, Malcolm Lewis, Tamara Mallett, Heather Maxwell, Catherine O’ Brien, Yincent Tse, Manish D Sinha

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Abstract

* A total of 917 children and young people under 18 years with established renal failure (ERF) were receiving treatment at paediatric nephrology centres in 2014.

* At the census date (31st December 2014), 79.3% of prevalent paediatric patients aged <18 years had a functioning kidney transplant, 11.2% were receiving haemodialysis (HD) and 9.5% were receiving peritoneal dialysis (PD).

* In patients aged <16 years, prevalence of ERF was 60.4 per million age related population (pmarp) and the incidence 9.4 pmarp.

* The most common primary renal diagnosis was renal dysplasia ± reflux, present in 32.6% of prevalent paediatric patients aged <16 years.

* About a third of patients had one or more reported comorbidity at onset of renal replacement therapy (RRT).

* The improvement in rates of pre-emptive transplantation for those referred early has been maintained over the last 10 years at 37.5%, compared to 27.4% in 2000–2004.

* At transfer to adult services, 90.3% of patients had a functioning kidney transplant.

* Survival during childhood amongst children commencing RRT was the lowest in those aged less than two years compared to those aged 12 to less than 16 years with a hazard ratio of 4.1 (confidence interval 2.2–8.0), and in those receiving dialysis compared to having a functioning transplant with a hazard ratio of 6.3 (confidence interval 3.9–10.2)
Original languageEnglish
Pages (from-to)99-110
Number of pages12
JournalNephron
Volume132 Suppl 1
DOIs
Publication statusPublished - 19 Apr 2016

Keywords

  • Adolescents
  • Aetiology
  • Children
  • Demography
  • Established renal failure
  • Incidence
  • Prevalence
  • Pre-emptive transplantation
  • Renal replacement therapy
  • Survival
  • Young adults

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