Abstract
* A total of 917 children and young people under 18 years with established renal failure (ERF) were receiving treatment at paediatric nephrology centres in 2014.
* At the census date (31st December 2014), 79.3% of prevalent paediatric patients aged <18 years had a functioning kidney transplant, 11.2% were receiving haemodialysis (HD) and 9.5% were receiving peritoneal dialysis (PD).
* In patients aged <16 years, prevalence of ERF was 60.4 per million age related population (pmarp) and the incidence 9.4 pmarp.
* The most common primary renal diagnosis was renal dysplasia ± reflux, present in 32.6% of prevalent paediatric patients aged <16 years.
* About a third of patients had one or more reported comorbidity at onset of renal replacement therapy (RRT).
* The improvement in rates of pre-emptive transplantation for those referred early has been maintained over the last 10 years at 37.5%, compared to 27.4% in 2000–2004.
* At transfer to adult services, 90.3% of patients had a functioning kidney transplant.
* Survival during childhood amongst children commencing RRT was the lowest in those aged less than two years compared to those aged 12 to less than 16 years with a hazard ratio of 4.1 (confidence interval 2.2–8.0), and in those receiving dialysis compared to having a functioning transplant with a hazard ratio of 6.3 (confidence interval 3.9–10.2)
* At the census date (31st December 2014), 79.3% of prevalent paediatric patients aged <18 years had a functioning kidney transplant, 11.2% were receiving haemodialysis (HD) and 9.5% were receiving peritoneal dialysis (PD).
* In patients aged <16 years, prevalence of ERF was 60.4 per million age related population (pmarp) and the incidence 9.4 pmarp.
* The most common primary renal diagnosis was renal dysplasia ± reflux, present in 32.6% of prevalent paediatric patients aged <16 years.
* About a third of patients had one or more reported comorbidity at onset of renal replacement therapy (RRT).
* The improvement in rates of pre-emptive transplantation for those referred early has been maintained over the last 10 years at 37.5%, compared to 27.4% in 2000–2004.
* At transfer to adult services, 90.3% of patients had a functioning kidney transplant.
* Survival during childhood amongst children commencing RRT was the lowest in those aged less than two years compared to those aged 12 to less than 16 years with a hazard ratio of 4.1 (confidence interval 2.2–8.0), and in those receiving dialysis compared to having a functioning transplant with a hazard ratio of 6.3 (confidence interval 3.9–10.2)
| Original language | English |
|---|---|
| Pages (from-to) | 99-110 |
| Number of pages | 12 |
| Journal | Nephron |
| Volume | 132 Suppl 1 |
| DOIs | |
| Publication status | Published - 19 Apr 2016 |
Keywords
- Adolescents
- Aetiology
- Children
- Demography
- Established renal failure
- Incidence
- Prevalence
- Pre-emptive transplantation
- Renal replacement therapy
- Survival
- Young adults