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UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence

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UKMenCar4 : A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence. / Bratcher, Holly B; Rodrigues, Charlene M C; Finn, Adam; Wootton, Mandy; Cameron, J Claire; Smith, Andrew; Heath, Paul; Ladhani, Shamez; Snape, Matthew D; Pollard, Andrew J; Cunningham, Richard; Borrow, Raymond; Trotter, Caroline; Gray, Stephen J; Maiden, Martin C J; MacLennan, Jenny M.

In: Wellcome Open Research, Vol. 4, 28.10.2019, p. 118.

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Bratcher, HB, Rodrigues, CMC, Finn, A, Wootton, M, Cameron, JC, Smith, A, Heath, P, Ladhani, S, Snape, MD, Pollard, AJ, Cunningham, R, Borrow, R, Trotter, C, Gray, SJ, Maiden, MCJ & MacLennan, JM 2019, 'UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence', Wellcome Open Research, vol. 4, pp. 118. https://doi.org/10.12688/wellcomeopenres.15362.2

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Bratcher, Holly B ; Rodrigues, Charlene M C ; Finn, Adam ; Wootton, Mandy ; Cameron, J Claire ; Smith, Andrew ; Heath, Paul ; Ladhani, Shamez ; Snape, Matthew D ; Pollard, Andrew J ; Cunningham, Richard ; Borrow, Raymond ; Trotter, Caroline ; Gray, Stephen J ; Maiden, Martin C J ; MacLennan, Jenny M. / UKMenCar4 : A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence. In: Wellcome Open Research. 2019 ; Vol. 4. pp. 118.

Bibtex

@article{239463b9ce0149788555c05d43c0095d,
title = "UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence",
abstract = "Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10{\%} of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.",
author = "Bratcher, {Holly B} and Rodrigues, {Charlene M C} and Adam Finn and Mandy Wootton and Cameron, {J Claire} and Andrew Smith and Paul Heath and Shamez Ladhani and Snape, {Matthew D} and Pollard, {Andrew J} and Richard Cunningham and Raymond Borrow and Caroline Trotter and Gray, {Stephen J} and Maiden, {Martin C J} and MacLennan, {Jenny M}",
note = "The acceptance date for this record is provisional and based upon the month of publication for the article.",
year = "2019",
month = "10",
day = "28",
doi = "10.12688/wellcomeopenres.15362.2",
language = "English",
volume = "4",
pages = "118",
journal = "Wellcome Open Research",
issn = "2398-502X",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - UKMenCar4

T2 - A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence

AU - Bratcher, Holly B

AU - Rodrigues, Charlene M C

AU - Finn, Adam

AU - Wootton, Mandy

AU - Cameron, J Claire

AU - Smith, Andrew

AU - Heath, Paul

AU - Ladhani, Shamez

AU - Snape, Matthew D

AU - Pollard, Andrew J

AU - Cunningham, Richard

AU - Borrow, Raymond

AU - Trotter, Caroline

AU - Gray, Stephen J

AU - Maiden, Martin C J

AU - MacLennan, Jenny M

N1 - The acceptance date for this record is provisional and based upon the month of publication for the article.

PY - 2019/10/28

Y1 - 2019/10/28

N2 - Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.

AB - Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999. The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.

U2 - 10.12688/wellcomeopenres.15362.2

DO - 10.12688/wellcomeopenres.15362.2

M3 - Article

C2 - 31544158

VL - 4

SP - 118

JO - Wellcome Open Research

JF - Wellcome Open Research

SN - 2398-502X

ER -