Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease

Ian D Jones, Virginia Luis Fuentes, Adrian Boswood, Melanie J Hezzell, David Wrigglesworth, Ana Mateus, Walasinee Moonarmart, Jonathan Elliott

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

OBJECTIVES: To measure flow-mediated vasodilation (FMD) in healthy dogs and in client-owned dogs with chronic valvular disease (CVD) and to investigate possible correlations between markers of CVD severity and FMD.

ANIMALS: Twelve dogs with CVD and 11 healthy weight-matched dogs.

METHODS: Brachial artery FMD following 5 min inflation of a cuff around the antebrachium was measured in 12 dogs with CVD and 11 healthy weight-matched dogs. Measurements were also obtained in the healthy dogs 5 min after cuff placement but without inflation ('sham cuff placement'). Dogs with CVD underwent echocardiography to confirm and characterize their disease.

RESULTS: In healthy dogs (median age 4 [2-6] years), median FMD was 7.7% versus 3.4% with sham cuff placement (P = 0.003). In dogs with CVD (median age 8 [4-16] years) median FMD was 5.5% versus 7.7% in healthy dogs (P = 0.131). FMD showed an inverse correlation with left ventricular end-diastolic diameter normalized for body weight (r = -0.76, P = 0.0043).

CONCLUSIONS: Brachial FMD in dogs with early CVD inversely correlates with severity of left ventricular remodelling.

Original languageEnglish
Pages (from-to)203-10
Number of pages8
JournalJournal of Veterinary Cardiology
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Animals
  • Brachial Artery
  • Chronic Disease
  • Dog Diseases
  • Dogs
  • Endothelium, Vascular
  • Mitral Valve Insufficiency
  • Ultrasonography
  • Vasodilation

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