Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease

Ian D Jones; Virginia Luis Fuentes; Adrian Boswood; Melanie J Hezzell; David Wrigglesworth; Ana Mateus; Walasinee Moonarmart; Jonathan Elliott

doi:10.1016/j.jvc.2011.09.004

Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease

Ian D Jones, Virginia Luis Fuentes, Adrian Boswood, Melanie J Hezzell, David Wrigglesworth, Ana Mateus, Walasinee Moonarmart, Jonathan Elliott

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Abstract

OBJECTIVES: To measure flow-mediated vasodilation (FMD) in healthy dogs and in client-owned dogs with chronic valvular disease (CVD) and to investigate possible correlations between markers of CVD severity and FMD.

ANIMALS: Twelve dogs with CVD and 11 healthy weight-matched dogs.

METHODS: Brachial artery FMD following 5 min inflation of a cuff around the antebrachium was measured in 12 dogs with CVD and 11 healthy weight-matched dogs. Measurements were also obtained in the healthy dogs 5 min after cuff placement but without inflation ('sham cuff placement'). Dogs with CVD underwent echocardiography to confirm and characterize their disease.

RESULTS: In healthy dogs (median age 4 [2-6] years), median FMD was 7.7% versus 3.4% with sham cuff placement (P = 0.003). In dogs with CVD (median age 8 [4-16] years) median FMD was 5.5% versus 7.7% in healthy dogs (P = 0.131). FMD showed an inverse correlation with left ventricular end-diastolic diameter normalized for body weight (r = -0.76, P = 0.0043).

CONCLUSIONS: Brachial FMD in dogs with early CVD inversely correlates with severity of left ventricular remodelling.

Original language	English
Pages (from-to)	203-10
Number of pages	8
Journal	Journal of Veterinary Cardiology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.jvc.2011.09.004
Publication status	Published - Mar 2012

Keywords

Animals
Brachial Artery
Chronic Disease
Dog Diseases
Dogs
Endothelium, Vascular
Mitral Valve Insufficiency
Ultrasonography
Vasodilation

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@article{cea0c308f99d4bee9ab58e9a1012b2a2,

title = "Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease",

abstract = "OBJECTIVES: To measure flow-mediated vasodilation (FMD) in healthy dogs and in client-owned dogs with chronic valvular disease (CVD) and to investigate possible correlations between markers of CVD severity and FMD.ANIMALS: Twelve dogs with CVD and 11 healthy weight-matched dogs.METHODS: Brachial artery FMD following 5 min inflation of a cuff around the antebrachium was measured in 12 dogs with CVD and 11 healthy weight-matched dogs. Measurements were also obtained in the healthy dogs 5 min after cuff placement but without inflation ('sham cuff placement'). Dogs with CVD underwent echocardiography to confirm and characterize their disease.RESULTS: In healthy dogs (median age 4 [2-6] years), median FMD was 7.7% versus 3.4% with sham cuff placement (P = 0.003). In dogs with CVD (median age 8 [4-16] years) median FMD was 5.5% versus 7.7% in healthy dogs (P = 0.131). FMD showed an inverse correlation with left ventricular end-diastolic diameter normalized for body weight (r = -0.76, P = 0.0043).CONCLUSIONS: Brachial FMD in dogs with early CVD inversely correlates with severity of left ventricular remodelling.",

keywords = "Animals, Brachial Artery, Chronic Disease, Dog Diseases, Dogs, Endothelium, Vascular, Mitral Valve Insufficiency, Ultrasonography, Vasodilation",

author = "Jones, {Ian D} and Fuentes, {Virginia Luis} and Adrian Boswood and Hezzell, {Melanie J} and David Wrigglesworth and Ana Mateus and Walasinee Moonarmart and Jonathan Elliott",

year = "2012",

month = mar,

doi = "10.1016/j.jvc.2011.09.004",

language = "English",

volume = "14",

pages = "203--10",

journal = "Journal of Veterinary Cardiology",

issn = "1875-0834",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease

AU - Jones, Ian D

AU - Fuentes, Virginia Luis

AU - Boswood, Adrian

AU - Hezzell, Melanie J

AU - Wrigglesworth, David

AU - Mateus, Ana

AU - Moonarmart, Walasinee

AU - Elliott, Jonathan

PY - 2012/3

Y1 - 2012/3

N2 - OBJECTIVES: To measure flow-mediated vasodilation (FMD) in healthy dogs and in client-owned dogs with chronic valvular disease (CVD) and to investigate possible correlations between markers of CVD severity and FMD.ANIMALS: Twelve dogs with CVD and 11 healthy weight-matched dogs.METHODS: Brachial artery FMD following 5 min inflation of a cuff around the antebrachium was measured in 12 dogs with CVD and 11 healthy weight-matched dogs. Measurements were also obtained in the healthy dogs 5 min after cuff placement but without inflation ('sham cuff placement'). Dogs with CVD underwent echocardiography to confirm and characterize their disease.RESULTS: In healthy dogs (median age 4 [2-6] years), median FMD was 7.7% versus 3.4% with sham cuff placement (P = 0.003). In dogs with CVD (median age 8 [4-16] years) median FMD was 5.5% versus 7.7% in healthy dogs (P = 0.131). FMD showed an inverse correlation with left ventricular end-diastolic diameter normalized for body weight (r = -0.76, P = 0.0043).CONCLUSIONS: Brachial FMD in dogs with early CVD inversely correlates with severity of left ventricular remodelling.

AB - OBJECTIVES: To measure flow-mediated vasodilation (FMD) in healthy dogs and in client-owned dogs with chronic valvular disease (CVD) and to investigate possible correlations between markers of CVD severity and FMD.ANIMALS: Twelve dogs with CVD and 11 healthy weight-matched dogs.METHODS: Brachial artery FMD following 5 min inflation of a cuff around the antebrachium was measured in 12 dogs with CVD and 11 healthy weight-matched dogs. Measurements were also obtained in the healthy dogs 5 min after cuff placement but without inflation ('sham cuff placement'). Dogs with CVD underwent echocardiography to confirm and characterize their disease.RESULTS: In healthy dogs (median age 4 [2-6] years), median FMD was 7.7% versus 3.4% with sham cuff placement (P = 0.003). In dogs with CVD (median age 8 [4-16] years) median FMD was 5.5% versus 7.7% in healthy dogs (P = 0.131). FMD showed an inverse correlation with left ventricular end-diastolic diameter normalized for body weight (r = -0.76, P = 0.0043).CONCLUSIONS: Brachial FMD in dogs with early CVD inversely correlates with severity of left ventricular remodelling.

KW - Animals

KW - Brachial Artery

KW - Chronic Disease

KW - Dog Diseases

KW - Dogs

KW - Endothelium, Vascular

KW - Mitral Valve Insufficiency

KW - Ultrasonography

KW - Vasodilation

U2 - 10.1016/j.jvc.2011.09.004

DO - 10.1016/j.jvc.2011.09.004

M3 - Article (Academic Journal)

C2 - 22366570

SN - 1875-0834

VL - 14

SP - 203

EP - 210

JO - Journal of Veterinary Cardiology

JF - Journal of Veterinary Cardiology

IS - 1

ER -

Ultrasonographic measurement of flow-mediated vasodilation in dogs with chronic valvular disease

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Keywords

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