TY - JOUR
T1 - Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.
AU - de Vivo, Luisa
AU - Bellesi, M
AU - Marshall, W
AU - Bushong, EA
AU - Ellisman, MH
AU - Tononi, G
AU - Cirelli, C
PY - 2017/2/3
Y1 - 2017/2/3
N2 - It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic and informational considerations suggest that potentiation should occur primarily during wake, when animals learn, and depression should occur during sleep. We measured 6920 synapses in mouse motor and sensory cortices using three-dimensional electron microscopy. The axon-spine interface (ASI) decreased ~18% after sleep compared with wake. This decrease was proportional to ASI size, which is indicative of scaling. Scaling was selective, sparing synapses that were large and lacked recycling endosomes. Similar scaling occurred for spine head volume, suggesting a distinction between weaker, more plastic synapses (~80%) and stronger, more stable synapses. These results support the hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake.
AB - It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic and informational considerations suggest that potentiation should occur primarily during wake, when animals learn, and depression should occur during sleep. We measured 6920 synapses in mouse motor and sensory cortices using three-dimensional electron microscopy. The axon-spine interface (ASI) decreased ~18% after sleep compared with wake. This decrease was proportional to ASI size, which is indicative of scaling. Scaling was selective, sparing synapses that were large and lacked recycling endosomes. Similar scaling occurred for spine head volume, suggesting a distinction between weaker, more plastic synapses (~80%) and stronger, more stable synapses. These results support the hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake.
UR - http://europepmc.org/abstract/med/28154076
U2 - 10.1126/science.aah5982
DO - 10.1126/science.aah5982
M3 - Article (Academic Journal)
C2 - 28154076
VL - 355
SP - 507
EP - 510
JO - Science
JF - Science
SN - 0036-8075
IS - 6324
ER -