Ultraviolet B-induced inflammation in the rat: A model of secondary hyperalgesia?

Emily K Davies, Yvonne Boyle, Boris A Chizh, Bridget M Lumb, Joanna C Murrell

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Abstract

Cutaneous inflammation induced by ultraviolet (UV) irradiation in the UV-B range has received significant recent interest as a translational inflammatory pain model. Changes in thermal and mechanical sensitivities in the area of primary hyperalgesia are well documented in both the rat and human UV-B models, but the occurrence of secondary mechanical hyperalgesia is controversial. We investigated the occurrence of secondary mechanical hyperalgesia in the rat UV-B model. Additionally, we investigated whether secondary hyperalgesia was enhanced by heat rekindling of UV-B-irradiated skin as a new rat inflammatory model of sensitisation with an enhanced central contribution. UV-B irradiation (1000mJ/cm(2)) induced significant secondary mechanical hyperalgesia and allodynia that peaked at 48h. Heat rekindling (45°C stimulus for 5min) of UV-B-irradiated skin at 24h further enhanced and prolonged this secondary mechanical hyperalgesia and allodynia, with a peak at 72h. Heat rekindling also induced a significant mechanical hyperalgesia and allodynia on the contralateral hind paw, further suggesting the contribution of central sensitisation. Our data provide strong evidence for a central contribution in both the rat UV-B pain model and an enhanced contribution in the new model combining UV-B irradiation with heat rekindling. We also elucidate potential differences in the methods used by ourselves and others to obtain mechanical withdrawal thresholds in rats, which may explain the lack of secondary hyperalgesia in the rat UV-B model.
Translated title of the contributionUltraviolet B induced inflammation in the rat: A model of secondary hyperalgesia?
Original languageEnglish
Pages (from-to)2844 - 2851
Number of pages7
JournalPAIN
Volume152
Issue number12
DOIs
Publication statusPublished - Dec 2011

Bibliographical note

Other: PMID 22019137

Keywords

  • Animals
  • Dermatitis
  • Disease Models, Animal
  • Hyperalgesia
  • Inflammation Mediators
  • Male
  • Rats
  • Rats, Wistar
  • Ultraviolet Rays

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