Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy

Hemmen Sabir*, Sonia Bonifacio, Alistair Gunn, Marianne Thoresen, Lina Chalak

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


Therapeutic hypothermia (TH) is now well established to improve intact survival after neonatal encephalopathy (NE). However, many questions could not be addressed by the randomized controlled trials. Should late preterm newborns with NE be cooled? Is cooling beneficial for mild NE? Is the current therapeutic time window optimal, or could it be shortened or prolonged? Will either milder or deeper hypothermia be effective? Does infection/inflammation exposure in the perinatal period in combination with NE offer potentially beneficial preconditioning or might it obviate hypothermic neuroprotection? In the present review, we dissect the evidence, for whom, when and how can TH best be delivered, and highlight areas that need further research.
Original languageEnglish
Article number101257
Number of pages8
JournalSeminars in Fetal and Neonatal Medicine
Early online date12 Jun 2021
Publication statusE-pub ahead of print - 12 Jun 2021

Bibliographical note

Funding Information:
We would like to thank Julia Gundersen for providing Fig. 1.

Publisher Copyright:
© 2021


  • Newborn
  • Neonatal encephalopathy
  • Hypoxia-ischemia
  • Therapeutic hypothermia
  • Infection


Dive into the research topics of 'Unanswered questions regarding therapeutic hypothermia for neonates with neonatal encephalopathy'. Together they form a unique fingerprint.

Cite this