Unbiased entropy estimates in stress: a parameter study

Aleksandar Boskovic; Tatjana Loncar-Turukalo; Olivera Sarenac; Nina Japundzic-Zigon; Dragana Bajic

doi:10.1016/j.compbiomed.2012.03.003

Unbiased entropy estimates in stress: a parameter study

Aleksandar Boskovic, Tatjana Loncar-Turukalo, Olivera Sarenac, Nina Japundzic-Zigon, Dragana Bajic

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

Abstract

This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with different likelihood of developing cardiovascular disease--normal and borderline hypertensive rats--exposed to the acute and to the chronic stress. It is shown that the threshold level is the major source of the instability, and that the generally accepted and widely used methods for a threshold choice may lead to an incorrect psychological interpretation. A method for the threshold level correction is proposed.

Original language	English
Pages (from-to)	667-79
Number of pages	13
Journal	Computers in Biology and Medicine
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/j.compbiomed.2012.03.003
Publication status	Published - Jun 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Computational Biology
Entropy
Hypertension
Male
Models, Biological
ROC Curve
Rats
Rats, Inbred SHR
Rats, Wistar
Stress, Physiological
Journal Article
Research Support, Non-U.S. Gov't

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title = "Unbiased entropy estimates in stress: a parameter study",

abstract = "This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with different likelihood of developing cardiovascular disease--normal and borderline hypertensive rats--exposed to the acute and to the chronic stress. It is shown that the threshold level is the major source of the instability, and that the generally accepted and widely used methods for a threshold choice may lead to an incorrect psychological interpretation. A method for the threshold level correction is proposed.",

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author = "Aleksandar Boskovic and Tatjana Loncar-Turukalo and Olivera Sarenac and Nina Japundzic-Zigon and Dragana Bajic",

year = "2012",

month = jun,

doi = "10.1016/j.compbiomed.2012.03.003",

language = "English",

volume = "42",

pages = "667--79",

journal = "Computers in Biology and Medicine",

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TY - JOUR

T1 - Unbiased entropy estimates in stress

T2 - a parameter study

AU - Boskovic, Aleksandar

AU - Loncar-Turukalo, Tatjana

AU - Sarenac, Olivera

AU - Japundzic-Zigon, Nina

AU - Bajic, Dragana

PY - 2012/6

Y1 - 2012/6

N2 - This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with different likelihood of developing cardiovascular disease--normal and borderline hypertensive rats--exposed to the acute and to the chronic stress. It is shown that the threshold level is the major source of the instability, and that the generally accepted and widely used methods for a threshold choice may lead to an incorrect psychological interpretation. A method for the threshold level correction is proposed.

AB - This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with different likelihood of developing cardiovascular disease--normal and borderline hypertensive rats--exposed to the acute and to the chronic stress. It is shown that the threshold level is the major source of the instability, and that the generally accepted and widely used methods for a threshold choice may lead to an incorrect psychological interpretation. A method for the threshold level correction is proposed.

KW - Animals

KW - Computational Biology

KW - Entropy

KW - Hypertension

KW - Male

KW - Models, Biological

KW - ROC Curve

KW - Rats

KW - Rats, Inbred SHR

KW - Rats, Wistar

KW - Stress, Physiological

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.compbiomed.2012.03.003

DO - 10.1016/j.compbiomed.2012.03.003

M3 - Article (Academic Journal)

C2 - 22469553

SN - 0010-4825

VL - 42

SP - 667

EP - 679

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

IS - 6

ER -

Unbiased entropy estimates in stress: a parameter study

Abstract

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Keywords

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