Uncovering network systems within protein structures

LH Greene*, VA Higman

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

242 Citations (Scopus)

Abstract

Traditionally, proteins have been viewed as a construct based on elements of secondary structure and their arrangement in three-dimensional space. In a departure from this perspective we show that protein structures can be modelled as network systems that exhibit small-world, single-scale, and to some degree, scale-free properties. The phenomenological network concept of degrees of separation is applied to three-dimensional protein structure networks and reveals how amino acid residues can be connected to each other within six degrees of separation. This work also illuminates the unique features of protein networks in comparison to other networks currently studied. Recognising that proteins are networks provides a means of rationalising the robustness in the overall three-dimensional fold of a protein against random mutations and suggests an alternative avenue to investigate the determinants of protein structure, function and folding. (C) 2003 Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)781-791
Number of pages11
JournalJournal of Molecular Biology
Volume334
Issue number4
DOIs
Publication statusPublished - 5 Dec 2003

Keywords

  • networks
  • MOTIFS
  • protein folding
  • protein structure
  • COMPLEX NETWORKS
  • SMALL-WORLD NETWORKS
  • UNIVERSE
  • TOPOLOGY
  • MODEL
  • scale-free
  • CLASSIFICATION
  • CONNECTANCE
  • small-world
  • EVOLUTION

Fingerprint

Dive into the research topics of 'Uncovering network systems within protein structures'. Together they form a unique fingerprint.

Cite this