Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Louis Luk; Will M Dawson; Maite Roca; Vincent Moliner; Rudolf Allemann; Adrian J Mulholland; Jeremy N Harvey; David R Glowacki; Joel Loveridge; José Javier Ruiz Pernia; Iñaki  Tuñón

doi:10.1073/pnas.1312437110

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Louis Luk, Will M Dawson, Maite Roca, Vincent Moliner, Rudolf Allemann, Adrian J Mulholland, Jeremy N Harvey, David R Glowacki, Joel Loveridge, José Javier Ruiz Pernia, Iñaki Tuñón

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Original language	English
Pages (from-to)	16344–16349
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	110
Issue number	41
DOIs	https://doi.org/10.1073/pnas.1312437110
Publication status	Published - 8 Oct 2013

Research Groups and Themes

Physical & Theoretical

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Protein-ligand coupled motions in DHFR catalysis
Crump, M. P. (Principal Investigator)
31/07/12 → 31/07/15
Project: Research
CCP-BioSim: Biomolecular simulation at the life sciences interface
Mulholland, A. J. (Principal Investigator)
1/10/11 → 1/10/15
Project: Research
COMPUTATIONAL BIOCHEMISTRY: PREDICTIVE MODELLING FOR BIOLOGY AND MEDICINE
Mulholland, A. J. (Principal Investigator)
1/10/08 → 1/04/14
Project: Research

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Luk, L., Dawson, W. M., Roca, M., Moliner, V., Allemann, R., Mulholland, A. J., Harvey, J. N., Glowacki, D. R., Loveridge, J., Javier Ruiz Pernia, J., & Tuñón , I. (2013). Unraveling the role of protein dynamics in dihydrofolate reductase catalysis. Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16344–16349. https://doi.org/10.1073/pnas.1312437110

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title = "Unraveling the role of protein dynamics in dihydrofolate reductase catalysis",

author = "Louis Luk and Dawson, \{Will M\} and Maite Roca and Vincent Moliner and Rudolf Allemann and Mulholland, \{Adrian J\} and Harvey, \{Jeremy N\} and Glowacki, \{David R\} and Joel Loveridge and \{Javier Ruiz Pernia\}, Jos{\'e} and I{\~n}aki Tu{\~n}{\'o}n",

year = "2013",

month = oct,

day = "8",

doi = "10.1073/pnas.1312437110",

language = "English",

volume = "110",

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Luk, L, Dawson, WM, Roca, M, Moliner, V, Allemann, R, Mulholland, AJ, Harvey, JN, Glowacki, DR, Loveridge, J, Javier Ruiz Pernia, J & Tuñón , I 2013, 'Unraveling the role of protein dynamics in dihydrofolate reductase catalysis', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 41, pp. 16344–16349. https://doi.org/10.1073/pnas.1312437110

TY - JOUR

T1 - Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

AU - Luk, Louis

AU - Dawson, Will M

AU - Roca, Maite

AU - Moliner, Vincent

AU - Allemann, Rudolf

AU - Mulholland, Adrian J

AU - Harvey, Jeremy N

AU - Glowacki, David R

AU - Loveridge, Joel

AU - Javier Ruiz Pernia, José

AU - Tuñón , Iñaki

PY - 2013/10/8

Y1 - 2013/10/8

U2 - 10.1073/pnas.1312437110

DO - 10.1073/pnas.1312437110

M3 - Article (Academic Journal)

C2 - 24065822

SN - 0027-8424

VL - 110

SP - 16344

EP - 16349

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 41

ER -

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Research Groups and Themes

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Projects

Protein-ligand coupled motions in DHFR catalysis

CCP-BioSim: Biomolecular simulation at the life sciences interface

COMPUTATIONAL BIOCHEMISTRY: PREDICTIVE MODELLING FOR BIOLOGY AND MEDICINE

Cite this