Abstract
Dynamic rearrangements in the actin cytoskeleton underlie a wide range of cell behaviours, which in turn contribute to many aspects of human health including embryogenesis, cancer metastasis, wound healing, and inflammation. Precise control of the actin cytoskeleton requires the coordinated activity of a diverse set of different actin regulators. However, our current understanding of the actin cytoskeleton has focused on how individual actin regulatory pathways function in isolation from one another. Recently, competition has emerged as a means by which different actin assembly factors can influence each other's activity at the cellular level. Here such findings will be used to explore the possibility that competition within the actin cytoskeleton confers cellular plasticity and the ability to prioritise multiple conflicting stimuli.
| Original language | English |
|---|---|
| Pages (from-to) | 569-576 |
| Number of pages | 8 |
| Journal | Trends in Cell Biology |
| Volume | 26 |
| Issue number | 8 |
| Early online date | 25 Apr 2016 |
| DOIs | |
| Publication status | Published - Aug 2016 |
Keywords
- actin
- cytoskeleton
- competition
- chemotaxis
- lamellipod
- filopod
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This is the final published version of the article (version of record). It first appeared online via Elsevier (Cell) at http://www.sciencedirect.com/science/article/pii/S0962892416300034. Please refer to any applicable terms of use of the publisher.