Unravelling the different functions of protein kinase C isoforms in platelets

Johan W M Heemskerk, Matthew T Harper, Judith M E M Cosemans, Alastair W Poole

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Abstract

Platelets tightly regulate haemostasis and arterial thrombosis. Protein kinase C (PKC) is involved in most platelet responses implicated in thrombus formation. Recent pharmacological and mouse gene knockout approaches show that the conventional PKC isoforms and the novel PKC isoforms contribute in distinct ways to these platelet responses. We hypothesize that, in platelets and other cells, the characteristic functions of PKC isoforms are established through unique activation mechanisms and unique interacting protein partners, which result in isoform-specific patterns of substrate phosphorylation. For identifying the substrate proteins in a living cell, new methodology is available and discussed.
Translated title of the contributionUnravelling the different functions of protein kinase C isoforms in platelets
Original languageEnglish
Pages (from-to)1711-6
Number of pages5
JournalFEBS Letters
Volume585
Issue number12
DOIs
Publication statusPublished - 23 Jun 2011

Bibliographical note

Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Keywords

  • Animals
  • Blood Platelets
  • Phosphorylation
  • Humans
  • Isoenzymes
  • Proteins
  • Platelet Activation
  • Protein Kinase C

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