Abstract
Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.
| Translated title of the contribution | Upstream Binding Factor is sequestered into Herpes Simplex Virus type 1 replication compartments |
|---|---|
| Original language | English |
| Pages (from-to) | 69 - 73 |
| Number of pages | 5 |
| Journal | Journal of General Virology |
| Volume | 90 |
| DOIs | |
| Publication status | Published - Jan 2009 |