Upstream Binding Factor is sequestered into Herpes Simplex Virus type 1 replication compartments

ND Stow, VC Evans, DA Matthews

Research output: Contribution to journalArticle (Academic Journal)peer-review

13 Citations (Scopus)

Abstract

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.
Translated title of the contributionUpstream Binding Factor is sequestered into Herpes Simplex Virus type 1 replication compartments
Original languageEnglish
Pages (from-to)69 - 73
Number of pages5
JournalJournal of General Virology
Volume90
DOIs
Publication statusPublished - Jan 2009

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