Use of 5-bromo-4-chloro-3-indolyl-∅-D-N-acetylneuraminic acid in a novel spot test to identify sialidase activity in vaginal swabs from women with bacterial vaginosis

R. Wiggins, T. Crowley, P. J. Horner*, P. W. Soothill, M. R. Millar, A. P. Corfield

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Abstract

The validity of measuring vaginal sialidase activity to identify bacterial vaginosis (BV) was determined by using 5-bromo-4-chloro-3-indolyl-α-D-N-acetylneuraminic acid in a near-patient test. The sensitivity and specificity of the test for prediction of BV were 95.6 and 96.3%, respectively. Positive and negative predictive values were 95.6 and 96.3%, respectively. This test may be an alternative to Gram staining.

Original languageEnglish
Pages (from-to)3096-3097
Number of pages2
JournalJournal of Clinical Microbiology
Volume38
Issue number8
Publication statusPublished - 2000

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