TY - JOUR
T1 - Use of magnetic resonance angiography to select candidates with recently symptomatic carotid stenosis for surgery: systematic review.
AU - ME, Westwood
AU - Kelly, S
AU - Berry, E
AU - Bamford, John
AU - MJ, Gough
AU - CM, Airey
AU - JF, Meaney
AU - LM, Davies
AU - Cullingworth, J
AU - MA, Smith
PY - 2002/1/1
Y1 - 2002/1/1
N2 - ObjectiveTo determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery.DesignSystematic review of published research on the diagnostic performance of magnetic resonance angiography, 1990-9.Main outcome measuresPerformance characteristics of diagnostic test.Results126 potentially relevant articles were identified, but many articles failed to examine the performance of magnetic resonance angiography as a diagnostic test at the surgical decision thresholds used in major clinical trials on endarterectomy. 26 articles were included in a meta-analysis that showed a maximal joint sensitivity and specificity of 99% (95% confidence interval 98% to 100%) for identifying 70-99% stenosis and 90% (81% to 99%) for identifying 50-99% stenosis. Only four articles evaluated contrast enhanced magnetic resonance angiography.ConclusionsMagnetic resonance angiography is accurate for selecting patients for carotid endarterectomy at the surgical decision thresholds established in the major endarterectomy trials, but the evidence is not very robust because of the heterogeneity of the studies included. Research is needed to determine the diagnostic performance of the most recent developments in magnetic resonance angiography, including contrast enhanced techniques, as well as to assess the impact of magnetic resonance angiography on surgical decision making and outcomes.
AB - ObjectiveTo determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery.DesignSystematic review of published research on the diagnostic performance of magnetic resonance angiography, 1990-9.Main outcome measuresPerformance characteristics of diagnostic test.Results126 potentially relevant articles were identified, but many articles failed to examine the performance of magnetic resonance angiography as a diagnostic test at the surgical decision thresholds used in major clinical trials on endarterectomy. 26 articles were included in a meta-analysis that showed a maximal joint sensitivity and specificity of 99% (95% confidence interval 98% to 100%) for identifying 70-99% stenosis and 90% (81% to 99%) for identifying 50-99% stenosis. Only four articles evaluated contrast enhanced magnetic resonance angiography.ConclusionsMagnetic resonance angiography is accurate for selecting patients for carotid endarterectomy at the surgical decision thresholds established in the major endarterectomy trials, but the evidence is not very robust because of the heterogeneity of the studies included. Research is needed to determine the diagnostic performance of the most recent developments in magnetic resonance angiography, including contrast enhanced techniques, as well as to assess the impact of magnetic resonance angiography on surgical decision making and outcomes.
UR - https://europepmc.org/articles/PMC64789
U2 - 10.1136/bmj.324.7331.198
DO - 10.1136/bmj.324.7331.198
M3 - Article (Academic Journal)
C2 - 11809640
SN - 0267-0623
JO - BMJ (Clinical Research ed.)
JF - BMJ (Clinical Research ed.)
ER -