Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions

L. D. Elliott; J. P. Knowles; C. S. Stacey; D. J. Klauber; K. I. Booker-Milburn

doi:10.1039/c7re00193b

Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions

L. D. Elliott, J. P. Knowles, C. S. Stacey, D. J. Klauber, K. I. Booker-Milburn^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The perceived difficulty of the scale-up of photochemistry is one of the main obstacles preventing its widespread use. Herein, we take three different challenging reactions and show that they can be reliably scaled, from immersion well batch reactors to higher power FEP flow reactors. Key to the success has been the development of a powerful calculation methodology which enables the accurate calculation of reactor flow rates from these and previously optimised batch reactions. Despite the challenging nature of these systems, in all cases tens of grams of material was obtained.

Original language	English
Pages (from-to)	86-93
Number of pages	8
Journal	Reaction Chemistry and Engineering
Volume	3
Issue number	1
DOIs	https://doi.org/10.1039/c7re00193b https://doi.org/10.1039/c7re00193b
Publication status	Published - 14 Feb 2018

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Royal Society of Chemistry at http://pubs.rsc.org/en/content/articlehtml/2018/re/c7re00193b. Please refer to any applicable terms of use of the publisher.
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AU - Booker-Milburn, K. I.

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AB - The perceived difficulty of the scale-up of photochemistry is one of the main obstacles preventing its widespread use. Herein, we take three different challenging reactions and show that they can be reliably scaled, from immersion well batch reactors to higher power FEP flow reactors. Key to the success has been the development of a powerful calculation methodology which enables the accurate calculation of reactor flow rates from these and previously optimised batch reactions. Despite the challenging nature of these systems, in all cases tens of grams of material was obtained.

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Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions

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