Using chirality to influence supramolecular gelation

Kate McAulay; Bart Dietrich; Hao Su; Michael T. Scott; Sarah Rogers; Youssra K. Al-Hilaly; Honggang Cui; Louise C. Serpell; Annela M. Seddon; Emily R. Draper; Dave J. Adams

doi:10.1039/c9sc02239b

Using chirality to influence supramolecular gelation

Kate McAulay, Bart Dietrich, Hao Su, Michael T. Scott, Sarah Rogers, Youssra K. Al-Hilaly, Honggang Cui, Louise C. Serpell, Annela M. Seddon, Emily R. Draper, Dave J. Adams^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

Original language	English
Pages (from-to)	7801-7806
Number of pages	6
Journal	Chemical Science
Volume	10
Issue number	33
Early online date	3 Jul 2019
DOIs	https://doi.org/10.1039/c9sc02239b
Publication status	E-pub ahead of print - 3 Jul 2019

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title = "Using chirality to influence supramolecular gelation",

abstract = "Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.",

author = "Kate McAulay and Bart Dietrich and Hao Su and Scott, {Michael T.} and Sarah Rogers and Al-Hilaly, {Youssra K.} and Honggang Cui and Serpell, {Louise C.} and Seddon, {Annela M.} and Draper, {Emily R.} and Adams, {Dave J.}",

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TY - JOUR

T1 - Using chirality to influence supramolecular gelation

AU - McAulay, Kate

AU - Dietrich, Bart

AU - Su, Hao

AU - Scott, Michael T.

AU - Rogers, Sarah

AU - Al-Hilaly, Youssra K.

AU - Cui, Honggang

AU - Serpell, Louise C.

AU - Seddon, Annela M.

AU - Draper, Emily R.

AU - Adams, Dave J.

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

AB - Most low molecular weight gelators are chiral, with racemic mixtures often unable to form gels. Here, we show an example where all enantiomers, diastereomers and racemates of a single functionalized dipeptide can form gels. At high pH, different self-assembled aggregates are formed and these directly template the structures formed in the gel. Hence, solutions and gels with different properties can be accessed simply by varying the chirality. This opens up new design rules for the field.

UR - http://www.scopus.com/inward/record.url?scp=85071226827&partnerID=8YFLogxK

U2 - 10.1039/c9sc02239b

DO - 10.1039/c9sc02239b

M3 - Article (Academic Journal)

C2 - 31588329

AN - SCOPUS:85071226827

SN - 2041-6520

VL - 10

SP - 7801

EP - 7806

JO - Chemical Science

JF - Chemical Science

IS - 33

ER -

Using chirality to influence supramolecular gelation

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