Using genetics to examine a general liability to childhood psychopathology

Lucy Riglin; Ajay Thapar; Beate Leppert; Joanna Martin; Alexander Richards; Richard Anney; George Davey Smith; Kate M Tilling; Evangelia Stergiakouli; Benjamin  Lahey; Michael C O'Donovan; Stephan Collishaw; Anita Thapar

doi:10.1007/s10519-019-09985-4

Using genetics to examine a general liability to childhood psychopathology

Lucy Riglin, Ajay Thapar, Beate Leppert, Joanna Martin, Alexander Richards, Richard Anney, George Davey Smith, Kate M Tilling, Evangelia Stergiakouli, Benjamin Lahey, Michael C O'Donovan, Stephan Collishaw, Anita Thapar

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Abstract

Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.

Original language	English
Number of pages	8
Journal	Behavior Genetics
Early online date	11 Dec 2019
DOIs	https://doi.org/10.1007/s10519-019-09985-4
Publication status	E-pub ahead of print - 11 Dec 2019

Keywords

ALSPAC
Psychopathology
p-factor
Childhood
Polygenic risk scores
Genetic

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title = "Using genetics to examine a general liability to childhood psychopathology",

abstract = "Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.",

keywords = "ALSPAC, Psychopathology, p-factor, Childhood, Polygenic risk scores, Genetic",

author = "Lucy Riglin and Ajay Thapar and Beate Leppert and Joanna Martin and Alexander Richards and Richard Anney and {Davey Smith}, George and Tilling, {Kate M} and Evangelia Stergiakouli and Benjamin Lahey and O'Donovan, {Michael C} and Stephan Collishaw and Anita Thapar",

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AU - Riglin, Lucy

AU - Thapar, Ajay

AU - Leppert, Beate

AU - Martin, Joanna

AU - Richards, Alexander

AU - Anney, Richard

AU - Davey Smith, George

AU - Tilling, Kate M

AU - Stergiakouli, Evangelia

AU - Lahey, Benjamin

AU - O'Donovan, Michael C

AU - Collishaw, Stephan

AU - Thapar, Anita

PY - 2019/12/11

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N2 - Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.

AB - Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.

KW - ALSPAC

KW - Psychopathology

KW - p-factor

KW - Childhood

KW - Polygenic risk scores

KW - Genetic

U2 - 10.1007/s10519-019-09985-4

DO - 10.1007/s10519-019-09985-4

M3 - Article (Academic Journal)

C2 - 31828458

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

ER -

Using genetics to examine a general liability to childhood psychopathology

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Keywords

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