Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management

Nikhil K Khankari*, Jacob M Keaton, Venexia M Walker, Kyung M Lee, Megan Shuey, Shoa Clarke, Kent Heberer, Donald Miller, Peter Reaven, Julie Lynch, Marijana Vujkovic, Todd L Edwards

*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Original languageEnglish
Article number104038
JournalEBioMedicine
Volume80
Early online date29 Apr 2022
DOIs
Publication statusE-pub ahead of print - 29 Apr 2022

Bibliographical note

Funding Information:
We would like to acknowledge the Million Veteran Program (MVP) participants. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health (NIH), and by National Cancer Institute (NCI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), and National Institute of Neurological Disorders and Stroke (NINDS). The GTEx data used for this were obtained from dbGaP Accession number phs000424v7p2. GWAS summary statistics were for lipid traits were downloaded from the Global Lipids Genetics Consortium ( http://csg.sph.umich.edu//abecasis/public/lipids2013 ). GWAS summary statistics for the negative control trait (natural hair color) were downloaded from the UK Biobank (dataset: ukb-d-1747_5; https://gwas.mrcieu.ac.uk/datasets/ ). We want to acknowledge the participants and investigators of FinnGen study ( https://finngen.gitbook.io/documentation/ ). NKK is supported by NIH R00 CA215360. VMW is supported by the MRC Integrative Epidemiology Unit at the University of Bristol (MC UU 00011/1 and MC UU 00011/4).

Funding Information:
We would like to acknowledge the Million Veteran Program (MVP) participants. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health (NIH), and by National Cancer Institute (NCI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), and National Institute of Neurological Disorders and Stroke (NINDS). The GTEx data used for this were obtained from dbGaP Accession number phs000424v7p2. GWAS summary statistics were for lipid traits were downloaded from the Global Lipids Genetics Consortium (http://csg.sph.umich.edu//abecasis/public/lipids2013). GWAS summary statistics for the negative control trait (natural hair color) were downloaded from the UK Biobank (dataset: ukb-d-1747_5; https://gwas.mrcieu.ac.uk/datasets/). We want to acknowledge the participants and investigators of FinnGen study (https://finngen.gitbook.io/documentation/). NKK is supported by NIH R00 CA215360. VMW is supported by the MRC Integrative Epidemiology Unit at the University of Bristol (MC UU 00011/1 and MC UU 00011/4). Our analysis utilized only summary statistics from published GWAS. All GPGE summary statistics used in our analysis are provided in the Supplementary Materials.

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© 2022

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