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Using openly accessible resources to strengthen causal inference in epigenetic epidemiology of neurodevelopment and mental health

Research output: Contribution to journalReview article

Original languageEnglish
Article number193
Number of pages21
JournalGenes
Volume10
Issue number3
DOIs
DateAccepted/In press - 25 Feb 2019
DatePublished (current) - 1 Mar 2019

Abstract

The recent focus on the role of epigenetic mechanisms in mental health has led to several studies examining the association of epigenetic processes with psychiatric conditions and neurodevelopmental traits. Some studies suggest that epigenetic changes might be causal in the development of the psychiatric condition under investigation. However, other scenarios are possible, e.g. statistical confounding or reverse causation, making it particularly challenging to derive conclusions on causality. In the present review, we examine the evidence from human population studies for a possible role of epigenetic mechanisms in neurodevelopment and mental health and discuss methodological approaches on how to strengthen causal inference including the need for replication, (quasi-)experimental approaches and Mendelian randomization. We signpost openly accessible resources (e.g. MR-Base, EWAS catalog, tissue-specific methylation and gene expression databases) to aid the application of these approaches.

    Research areas

  • Causal inference, DNA methylation, Epigenetics, Mendelian randomization, Mental health, Neurodevelopment

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via MDPI at https://www.mdpi.com/2073-4425/10/3/193 . Please refer to any applicable terms of use of the publisher.

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    Licence: CC BY

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