Using Oral Microbiota Data to Design a Short Sucrose Intake Index

Anders Esberg, Linda Eriksson, Pamela Hasslöf, Simon Haworth, Pernilla Lif Holgerson, Ingegerd Johansson

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Abstract

Excessive sucrose consumption is associated with numerous health problems, including dental caries, and is considered to play a critical role in shaping the human microbiota. Here, we aimed to confirm the association between sucrose exposure and oral microbiota profile, develop a short food-based index capturing variation among sucrose consumers and validate it against oral microbiota and dental caries in a derivation cohort with 16- to 79-year-old participants (n = 427). Intake and food preferences were recorded by questionnaires and saliva microbiota by 16S rDNA sequencing. Taxonomic similarities clustered participants into five clusters, where one stood out with highest sucrose intake and predicted sugar related metabolic pathways but lowest species diversity in the microbiota. Multivariate modelling of food intake and preferences revealed foods suitable for a sucrose index. This, similarly to sucrose intake, was related to bacterial pattern and caries status. The validity of the sucrose index was replicated in the population-based Gene-Lifestyle Interactions in Dental Endpoints (GLIDE, n = 105,520 Swedish adults) cohort. This suggested that the index captured clinically relevant variation in sucrose intake and that FFQ derived information may be suitable for screening of sucrose intake in the clinic and epidemiological studies, although adjustments to local consumption habits are needed.

Original languageEnglish
Article number1400
JournalNutrients
Volume13
Issue number5
DOIs
Publication statusPublished - 21 Apr 2021

Bibliographical note

Funding Information:
This research was funded by the Swedish Research Council (grant number 2011-03372 and 2015-02597, I.J.), The Swedish Patent Revenue Fund (grant 2017-019, I.J.), and the County Council of V?sterbotten Internal Research Foundation, grant number VLL-831231 (L.E.). The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Funding Information:
Funding: This research was funded by the Swedish Research Council (grant number 2011-03372 and 2015-02597, I.J.), The Swedish Patent Revenue Fund (grant 2017-019, I.J.), and the County Council of Västerbotten Internal Research Foundation, grant number VLL-831231 (L.E.). The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Adolescent
  • Adult
  • Aged
  • Bacteria/genetics
  • Cohort Studies
  • Dental Caries/microbiology
  • Dietary Sucrose/pharmacology
  • Female
  • Humans
  • Least-Squares Analysis
  • Male
  • Microbiota/drug effects
  • Middle Aged
  • Mouth/microbiology
  • Principal Component Analysis
  • RNA, Ribosomal, 16S/genetics
  • Statistics, Nonparametric
  • Young Adult

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