Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome

Max Crispin, David J Harvey, David Bitto, Steinar Halldorsson, Camille Bonomelli, Matthew Edgeworth, James H Scrivens, Juha T Huiskonen, Thomas A Bowden

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

Original languageEnglish
Pages (from-to)10244-51
Number of pages8
JournalJournal of Virology
Volume88
Issue number17
DOIs
Publication statusPublished - 1 Sep 2014

Keywords

  • Glucans/analysis
  • Glycomics
  • Glycoproteins/chemistry
  • Humans
  • Uukuniemi virus/physiology
  • Viral Proteins/chemistry
  • Virion/chemistry
  • Virus Assembly
  • Virus Release

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