Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children

P. Maghsoudlou; A. R. Abraham; M. El-Ashry; C. Chew; N. Mohd; A. V. Ramanan; A. D. Dick

doi:10.1080/09273948.2023.2282610

Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children

P. Maghsoudlou, A. R. Abraham, M. El-Ashry, C. Chew, N. Mohd, A. V. Ramanan, A. D. Dick^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

5 Citations (Scopus)

Abstract

Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.

Original language	English
Pages (from-to)	1930-1943
Number of pages	14
Journal	Ocular Immunology and Inflammation
Volume	31
Issue number	10
DOIs	https://doi.org/10.1080/09273948.2023.2282610
Publication status	Published - 5 Dec 2023

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

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title = "Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children",

abstract = "Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.",

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AU - Maghsoudlou, P.

AU - Abraham, A. R.

AU - El-Ashry, M.

AU - Chew, C.

AU - Mohd, N.

AU - Ramanan, A. V.

AU - Dick, A. D.

PY - 2023/12/5

Y1 - 2023/12/5

N2 - Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.

AB - Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.

U2 - 10.1080/09273948.2023.2282610

DO - 10.1080/09273948.2023.2282610

M3 - Review article (Academic Journal)

C2 - 38051595

SN - 0927-3948

VL - 31

SP - 1930

EP - 1943

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 10

ER -

Uveitis Associated with Monogenic Autoinflammatory Syndromes in Children

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