Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening

A. E. Nicoll, F. Mackenzie, I. A. Greer, J. E. Norman

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

OBJECTIVE: Our aim was to assess the effects of vaginally administered isosorbide mononitrate (a nitric oxide donor) on maternal and fetal hemodynamics in pregnant women at term.STUDY DESIGN: We conducted a randomized controlled trial. Women were randomly selected to receive vaginally administered isosorbide mononitrate, 20 mg (n = 13) or 40 mg (n = 11), or to undergo a vaginal examination only (n = 12). Maternal pulse, blood pressure, and fetal heart rate were recorded at baseline and then every 30 minutes until 360 minutes. Umbilical artery resistance index and pulsatility index measurements were performed at 0, 180, and 330 minutes.RESULTS: Maternal pulse rate was greater after the administration of isosorbide mononitrate, 20 or 40 mg, compared with the pulse rate in the vaginal examination-only group (greatest difference in means, 21 beats/min; P
Original languageEnglish
Pages (from-to)958-964
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume184
Issue number5
DOIs
Publication statusPublished - 2001

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Keywords

  • Adolescent Adult Apgar Score Blood Pressure Cervical Ripening Drug Administration Routes Female Fetus Heart Rate Heart Rate, Fetal Hemodynamics Humans Infant, Newborn Isosorbide Dinitrate Labor, Induced Nitric Oxide Donors Pregnancy Umbilical Arteries Vagina

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