Vascular and myometrial changes in the human uterus at term

Anthony S. Y. Leong, Jane E. Norman, Roger Smith

Research output: Contribution to journalArticle (Academic Journal)peer-review


At term, amniotic fluid contents may mediate the onset of labor through the activation of amniotic fluid macrophages and their migration into the myometrium. To test this concept, the authors examine the histological changes that occur in myometrial biopsies at term prior to (n = 53) and during (n = 15) labor. Biopsies were stained with an antimacrophage antibody, anti-CD34 (endothelial cells), and anti-caspase 3 (apoptotic cells). The samples showed a variable inflammatory infiltrate of neutrophils and macrophages, with a greater infiltrate in the samples obtained during labor (P
Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalReproductive Sciences
Issue number1
Publication statusPublished - 2008

Bibliographical note

RIS file


  • Antigens, CD Antigens, Differentiation, Myelomonocytic Apoptosis Caspase 3 Cell Movement Endothelial Cells Female Humans Inflammation Macrophages Myometrium Neutrophils Parturition Pregnancy


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