Vascular and myometrial changes in the human uterus at term

Anthony S. Y. Leong; Jane E. Norman; Roger Smith

doi:10.1177/1933719107309646

Vascular and myometrial changes in the human uterus at term

Anthony S. Y. Leong, Jane E. Norman, Roger Smith

Health Sciences Faculty Office

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Abstract

At term, amniotic fluid contents may mediate the onset of labor through the activation of amniotic fluid macrophages and their migration into the myometrium. To test this concept, the authors examine the histological changes that occur in myometrial biopsies at term prior to (n = 53) and during (n = 15) labor. Biopsies were stained with an antimacrophage antibody, anti-CD34 (endothelial cells), and anti-caspase 3 (apoptotic cells). The samples showed a variable inflammatory infiltrate of neutrophils and macrophages, with a greater infiltrate in the samples obtained during labor (P

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Reproductive Sciences
Volume	15
Issue number	1
DOIs	https://doi.org/10.1177/1933719107309646
Publication status	Published - 2008

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Keywords

Antigens, CD Antigens, Differentiation, Myelomonocytic Apoptosis Caspase 3 Cell Movement Endothelial Cells Female Humans Inflammation Macrophages Myometrium Neutrophils Parturition Pregnancy

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title = "Vascular and myometrial changes in the human uterus at term",

abstract = "At term, amniotic fluid contents may mediate the onset of labor through the activation of amniotic fluid macrophages and their migration into the myometrium. To test this concept, the authors examine the histological changes that occur in myometrial biopsies at term prior to (n = 53) and during (n = 15) labor. Biopsies were stained with an antimacrophage antibody, anti-CD34 (endothelial cells), and anti-caspase 3 (apoptotic cells). The samples showed a variable inflammatory infiltrate of neutrophils and macrophages, with a greater infiltrate in the samples obtained during labor (P ",

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AU - Norman, Jane E.

AU - Smith, Roger

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Vascular and myometrial changes in the human uterus at term

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