Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome

S. Barratt, A. R. Medford, A. B. Millar

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)

Abstract

Acute respiratory distress syndrome (ARDS) is the most severe form of lung injury, characterised by alveolar oedema and vascular permeability, in part due to disruption of the alveolar capillary membrane integrity. Vascular endothelial growth factor (VEGF) was originally identified as a vascular permeability factor and has been implicated in the pathogenesis of acute lung injury/ARDS. This review describes our current knowledge of VEGF biology and summarises the literature investigating the potential role VEGF may play in normal lung maintenance and in the development of lung injury.

Original languageEnglish
Pages (from-to)329-342
Number of pages14
JournalRespiration
Volume87
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Acute lung injury
  • Acute respiratory distress syndrome
  • Vascular endothelial growth factor

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