Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): A paradox or paradigm?

ARL Medford, AB Millar

Research output: Contribution to journalArticle (Academic Journal)

90 Citations (Scopus)

Abstract

Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), remains a devastating condition with a high mortality. It is characterised by alveolar injury and increased pulmonary vascular permeability. Vascular endothelial cell growth factor (VEGF) was identified by its properties to increase permeability and act as a cellular growth factor, hence its potential for a key role in the pathogenesis of ALI/ARDS. This review describes the basic biology of VEGF and its receptors as an essential prerequisite to discussing the available and sometimes paradoxical published data, before considering a paradigm for the role of VEGF in the human lung.
Translated title of the contributionVascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): A paradox or paradigm?
Original languageEnglish
Pages (from-to)621 - 626
Number of pages6
JournalThorax
Volume61 (7)
DOIs
Publication statusPublished - Jul 2006

Bibliographical note

Publisher: BMJ Group

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