VEGF receptor trafficking in angiogenesis

Alice Scott, Harry Mellor

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)

Abstract

The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalling pathways to other RTKs (receptor tyrosine kinases); however, its intracellular trafficking is very different. Furthermore, VEGFR2 can form a complex with a range of different angiogenic regulators that in turn regulate the trafficking of VEGFR2 through the endosomal pathway. This regulated trafficking of VEGFR2 has important consequences for angiogenic signalling and is a clear demonstration of how the endosomal pathway plays a critical role in connecting receptor signalling pathways to cellular events.

Original languageEnglish
Pages (from-to)1184-8
Number of pages5
JournalBiochemical Society Transactions
Volume37
Issue numberPt 6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Endothelial Cells
  • Neovascularization, Physiologic
  • Receptor, Epidermal Growth Factor
  • Signal Transduction
  • Vascular Endothelial Growth Factor Receptor-2

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