Abstract
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalling pathways to other RTKs (receptor tyrosine kinases); however, its intracellular trafficking is very different. Furthermore, VEGFR2 can form a complex with a range of different angiogenic regulators that in turn regulate the trafficking of VEGFR2 through the endosomal pathway. This regulated trafficking of VEGFR2 has important consequences for angiogenic signalling and is a clear demonstration of how the endosomal pathway plays a critical role in connecting receptor signalling pathways to cellular events.
| Original language | English |
|---|---|
| Pages (from-to) | 1184-8 |
| Number of pages | 5 |
| Journal | Biochemical Society Transactions |
| Volume | 37 |
| Issue number | Pt 6 |
| DOIs | |
| Publication status | Published - Dec 2009 |
Keywords
- Endothelial Cells
- Neovascularization, Physiologic
- Receptor, Epidermal Growth Factor
- Signal Transduction
- Vascular Endothelial Growth Factor Receptor-2