Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: A functional magnetic resonance imaging study

SP David, MR Munafo, H Johansen-Berg, SM Smith, RD Rogers, PM Matthews, RT Walton

Research output: Contribution to journalArticle (Academic Journal)peer-review

217 Citations (Scopus)

Abstract

Background Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity. Methods: Twenty-six healthy right-handed volunteers (14 smokers and 12 nonsmoking controls) underwent functional magnetic resonance imaging (fMRI) during which neutral and smoking-related images were presented. Region of interest analyses were performed within the ventral striatum/nucleus accumbens (VS/NAc)for the contrast between smoking-related (SR) and nonsmoking related neutral (N) cues. Results. Group activation for SR versus N cues was observed in smokers but not in nonsmokers in medial orbitofrontal cortex, superior frontal gyrus, anterior cingulate cortex, and posterior fusiform gyrus using whole-brain corrected Z thresholds and in the ventral VS/NAc using uncorrected Z-statistics (smokers Z = 3.2). Region of interest analysis of signal change within ventral VS/NAc demonstrated significantly greater activation to SR versus N cues in smokers than controls. Conclusions: This is the first demonstration of greater VS/NAc activation in addicted smokers than nonsmokers presented with smoking-related cues using fMRI. Smokers, but not controls, demonstrated activation to SR versus N cues in a distributed reward signaling network consistent with cite reactivity studies of other drugs of abuse.
Translated title of the contributionVentral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: A functional magnetic resonance imaging study
Original languageEnglish
Pages (from-to)488 - 494
Number of pages7
JournalBiological Psychiatry
Volume58
DOIs
Publication statusPublished - 2005

Bibliographical note

Publisher: Elsevier

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