Abstract
α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.
Original language | English |
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Pages (from-to) | 10299-10302 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 53 |
Issue number | 74 |
DOIs | |
Publication status | Published - 29 Aug 2017 |
Keywords
- Journal Article