Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

Michael P O'Hagan, Javier Ramos-Soriano, Susanta Haldar, Sadiyah Sheikh, Juan C Morales, Adrian J Mulholland, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.

Original languageEnglish
Pages (from-to)5186-5189
Number of pages4
JournalChemical Communications
Volume56
Issue number38
DOIs
Publication statusPublished - 8 May 2020

Structured keywords

  • BCS and TECS CDTs

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