Projects per year
Abstract
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.
| Original language | English |
|---|---|
| Pages (from-to) | 5186-5189 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 56 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 8 May 2020 |
Structured keywords
- BCS and TECS CDTs
Access to Document
- Full-text PDF (accepted author manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Royal Society of Chemistry at https://doi.org/10.1039/D0CC01581D . Please refer to any applicable terms of use of the publisher.
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Dive into the research topics of 'Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology'. Together they form a unique fingerprint.Projects
- 2 Finished
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CCP-BioSim: Biomolecular Simulation at the Life Sciences Interface
1/07/15 → 30/04/21
Project: Research
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Predicting drug-target binding kinetics through multiscale simulations
1/05/15 → 30/04/19
Project: Research