Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation: A masked prospective study

DRIFT10 study group

doi:10.1111/dmcn.15294

Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation: A masked prospective study

DRIFT10 study group

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Abstract

AIM: We examined children 10 to 11 years after grade 3 or 4 intraventricular haemorrhage and ventricular dilation (IVHVD) and investigated whether the grade of IVHVD affected their visual outcome. We explored associations between visual outcomes with cognitive outcomes and extra support at school.

METHOD: The visual examinations were part of a 10-year follow-up study for children in a randomized trial. Testers followed a protocol and were masked to whether the child had experienced grade 3 or grade 4 IVHVD and all other data.

RESULTS: Thirty-two children were tested: 24 were male and mean (standard deviation) age was 10 years 5 months (1 year 2 months); range 8 years 9 months to 12 years 9 months. All had at least one visual impairment. The median (interquartile range) number of impairments per child was six (six to nine) for children who experienced a grade 4 IVHVD compared with three (two to four) for children who experienced a grade 3 IVHVD (p = 0.003). Each extra vision impairment per child was associated with increased educational support at school, after adjustment for developmental age equivalence (odds ratio = 1.7 [95% confidence interval 1.1-2.6], p = 0.015).

INTERPRETATION: Children who experience grade 3 or 4 IVHVD have a high level of visual morbidity at age 10 to 11 years. These children may have unmet visual needs and their outcomes might improve if these needs could be addressed.

Original language	English
Pages (from-to)	223-231
Number of pages	9
Journal	Developmental Medicine and Child Neurology
Volume	65
Issue number	2
Early online date	23 Jun 2022
DOIs	https://doi.org/10.1111/dmcn.15294
Publication status	E-pub ahead of print - 23 Jun 2022

Bibliographical note

Funding Information:
CW was supported by a National Institute for Health and Care Research senior research fellowship. PW was supported by the Health Technology Assessment NIHR grant for the DRIFT10 study. The original DRIFT study was funded by the James and Grace Anderson Trust and by Cerebra.

Publisher Copyright:
© 2022 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.

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title = "Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation: A masked prospective study",

abstract = "AIM: We examined children 10 to 11 years after grade 3 or 4 intraventricular haemorrhage and ventricular dilation (IVHVD) and investigated whether the grade of IVHVD affected their visual outcome. We explored associations between visual outcomes with cognitive outcomes and extra support at school.METHOD: The visual examinations were part of a 10-year follow-up study for children in a randomized trial. Testers followed a protocol and were masked to whether the child had experienced grade 3 or grade 4 IVHVD and all other data.RESULTS: Thirty-two children were tested: 24 were male and mean (standard deviation) age was 10 years 5 months (1 year 2 months); range 8 years 9 months to 12 years 9 months. All had at least one visual impairment. The median (interquartile range) number of impairments per child was six (six to nine) for children who experienced a grade 4 IVHVD compared with three (two to four) for children who experienced a grade 3 IVHVD (p = 0.003). Each extra vision impairment per child was associated with increased educational support at school, after adjustment for developmental age equivalence (odds ratio = 1.7 [95% confidence interval 1.1-2.6], p = 0.015).INTERPRETATION: Children who experience grade 3 or 4 IVHVD have a high level of visual morbidity at age 10 to 11 years. These children may have unmet visual needs and their outcomes might improve if these needs could be addressed.",

author = "{DRIFT10 study group} and Cathy Williams and Penny Warnes and Sally Jary and Grace Young and Blair, {Peter S} and Benton, {Christopher P} and Helen Miller and Andrew Whitelaw and Ian Pople and Karen Luyt",

note = "Funding Information: CW was supported by a National Institute for Health and Care Research senior research fellowship. PW was supported by the Health Technology Assessment NIHR grant for the DRIFT10 study. The original DRIFT study was funded by the James and Grace Anderson Trust and by Cerebra. Publisher Copyright: {\textcopyright} 2022 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.",

year = "2022",

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doi = "10.1111/dmcn.15294",

language = "English",

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TY - JOUR

T1 - Vision function in children 10 years after grade 3 or 4 intraventricular haemorrhage with ventricular dilation

T2 - A masked prospective study

AU - DRIFT10 study group

AU - Williams, Cathy

AU - Warnes, Penny

AU - Jary, Sally

AU - Young, Grace

AU - Blair, Peter S

AU - Benton, Christopher P

AU - Miller, Helen

AU - Whitelaw, Andrew

AU - Pople, Ian

AU - Luyt, Karen

N1 - Funding Information: CW was supported by a National Institute for Health and Care Research senior research fellowship. PW was supported by the Health Technology Assessment NIHR grant for the DRIFT10 study. The original DRIFT study was funded by the James and Grace Anderson Trust and by Cerebra. Publisher Copyright: © 2022 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.

PY - 2022/6/23

Y1 - 2022/6/23

N2 - AIM: We examined children 10 to 11 years after grade 3 or 4 intraventricular haemorrhage and ventricular dilation (IVHVD) and investigated whether the grade of IVHVD affected their visual outcome. We explored associations between visual outcomes with cognitive outcomes and extra support at school.METHOD: The visual examinations were part of a 10-year follow-up study for children in a randomized trial. Testers followed a protocol and were masked to whether the child had experienced grade 3 or grade 4 IVHVD and all other data.RESULTS: Thirty-two children were tested: 24 were male and mean (standard deviation) age was 10 years 5 months (1 year 2 months); range 8 years 9 months to 12 years 9 months. All had at least one visual impairment. The median (interquartile range) number of impairments per child was six (six to nine) for children who experienced a grade 4 IVHVD compared with three (two to four) for children who experienced a grade 3 IVHVD (p = 0.003). Each extra vision impairment per child was associated with increased educational support at school, after adjustment for developmental age equivalence (odds ratio = 1.7 [95% confidence interval 1.1-2.6], p = 0.015).INTERPRETATION: Children who experience grade 3 or 4 IVHVD have a high level of visual morbidity at age 10 to 11 years. These children may have unmet visual needs and their outcomes might improve if these needs could be addressed.

AB - AIM: We examined children 10 to 11 years after grade 3 or 4 intraventricular haemorrhage and ventricular dilation (IVHVD) and investigated whether the grade of IVHVD affected their visual outcome. We explored associations between visual outcomes with cognitive outcomes and extra support at school.METHOD: The visual examinations were part of a 10-year follow-up study for children in a randomized trial. Testers followed a protocol and were masked to whether the child had experienced grade 3 or grade 4 IVHVD and all other data.RESULTS: Thirty-two children were tested: 24 were male and mean (standard deviation) age was 10 years 5 months (1 year 2 months); range 8 years 9 months to 12 years 9 months. All had at least one visual impairment. The median (interquartile range) number of impairments per child was six (six to nine) for children who experienced a grade 4 IVHVD compared with three (two to four) for children who experienced a grade 3 IVHVD (p = 0.003). Each extra vision impairment per child was associated with increased educational support at school, after adjustment for developmental age equivalence (odds ratio = 1.7 [95% confidence interval 1.1-2.6], p = 0.015).INTERPRETATION: Children who experience grade 3 or 4 IVHVD have a high level of visual morbidity at age 10 to 11 years. These children may have unmet visual needs and their outcomes might improve if these needs could be addressed.

U2 - 10.1111/dmcn.15294

DO - 10.1111/dmcn.15294

M3 - Article (Academic Journal)

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SN - 0012-1622

VL - 65

SP - 223

EP - 231

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 2

ER -