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Vitamin D status in cats with Feline Immunodeficiency Virus

Research output: Contribution to journalArticle (Academic Journal)

Original languageEnglish
Pages (from-to)72-78
Number of pages7
JournalVeterinary Medicine and Science
Volume1
Issue number2
Early online date23 Nov 2015
DOIs
DateAccepted/In press - 27 Oct 2015
DateE-pub ahead of print - 23 Nov 2015
DatePublished (current) - 26 Nov 2015

Abstract

Feline immunodeficiency virus (FIV) is a lentivirus that can lead to a syndrome of acquired immune dysfunction. Infected cats often remain asymptomatic for several years before immune dysfunction leads to an increased risk for the development of systemic diseases, neoplasia and opportunistic infections. Feline immunodeficiency virus is structurally related to human immunodeficiency virus (HIV) and the pathogenesis of FIV-related disease is similar to that seen in HIV-infected patients.

Observational studies have documented an association between low plasma vitamin D and HIV infection. Vitamin D status has been shown to be associated with HIV-related disease progression, morbidity and mortality. The objective of this study was to examine the hypothesis that vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] concentrations, are lower in cats with FIV infection compared to healthy control cats. Serum 25(OH)D concentrations were measured in 20 healthy cats, 39 hospitalised ill cats and 59 cats infected with FIV. Cats which were FIV-infected had significantly lower 25(OH)D concentrations compared to healthy control cats. Serum 25(OH)D concentrations were not significantly different between FIV-infected cats and hospitalised ill cats. Further investigations are warranted to determine whether vitamin D status influences the prognosis of cats infected with FIV.

    Research areas

  • Vitamin D, feline, Feline Immunodeficiency Virus, 25(OH)D, Human Immunodeficiency Virus

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  • Titmarsh_et_al-2015-Veterinary_Medicine_&_Science

    Rights statement: © 2015 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

    Final published version, 80.1 KB, PDF document

    Licence: CC BY

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