Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome

Marianna Szemes, Rachel L Davies, Claire Lp Garden, Maria M Usowicz

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Abstract

Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of the brain regions most affected is the cerebellum, in which the number of granule cells (GCs) is markedly decreased. GCs process sensory information entering the cerebellum via mossy fibres and pass it on to Purkinje cells and inhibitory interneurons. How GCs transform incoming signals depends on their input-output relationship, which is adjusted by tonically active GABAA receptor channels.
Original languageEnglish
Pages (from-to)33
JournalMolecular Brain
Volume6
Issue number1
Early online date19 Jul 2013
DOIs
Publication statusPublished - 24 Jul 2013

Keywords

  • cerebellum, tonic inhibition, GABA-A receptor, granule neuron, Down Syndrome

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