Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome

Marianna Szemes; Rachel L Davies; Claire Lp Garden; Maria M Usowicz

doi:10.1186/1756-6606-6-33

Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome

Marianna Szemes, Rachel L Davies, Claire Lp Garden, Maria M Usowicz

Research output: Contribution to journal › Article (Academic Journal) › peer-review

13 Citations (Scopus)

Abstract

Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of the brain regions most affected is the cerebellum, in which the number of granule cells (GCs) is markedly decreased. GCs process sensory information entering the cerebellum via mossy fibres and pass it on to Purkinje cells and inhibitory interneurons. How GCs transform incoming signals depends on their input-output relationship, which is adjusted by tonically active GABAA receptor channels.

Original language	English
Pages (from-to)	33
Journal	Molecular Brain
Volume	6
Issue number	1
Early online date	19 Jul 2013
DOIs	https://doi.org/10.1186/1756-6606-6-33
Publication status	Published - 24 Jul 2013

Keywords

cerebellum, tonic inhibition, GABA-A receptor, granule neuron, Down Syndrome

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http://www.molecularbrain.com/content/6/1/33

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abstract = "Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of the brain regions most affected is the cerebellum, in which the number of granule cells (GCs) is markedly decreased. GCs process sensory information entering the cerebellum via mossy fibres and pass it on to Purkinje cells and inhibitory interneurons. How GCs transform incoming signals depends on their input-output relationship, which is adjusted by tonically active GABAA receptor channels.",

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AU - Szemes, Marianna

AU - Davies, Rachel L

AU - Garden, Claire Lp

AU - Usowicz, Maria M

PY - 2013/7/24

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N2 - Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of the brain regions most affected is the cerebellum, in which the number of granule cells (GCs) is markedly decreased. GCs process sensory information entering the cerebellum via mossy fibres and pass it on to Purkinje cells and inhibitory interneurons. How GCs transform incoming signals depends on their input-output relationship, which is adjusted by tonically active GABAA receptor channels.

AB - Down's syndrome (DS) is caused by triplication of all or part of human chromosome 21 and is characterized by a decrease in the overall size of the brain. One of the brain regions most affected is the cerebellum, in which the number of granule cells (GCs) is markedly decreased. GCs process sensory information entering the cerebellum via mossy fibres and pass it on to Purkinje cells and inhibitory interneurons. How GCs transform incoming signals depends on their input-output relationship, which is adjusted by tonically active GABAA receptor channels.

KW - cerebellum, tonic inhibition, GABA-A receptor, granule neuron, Down Syndrome

U2 - 10.1186/1756-6606-6-33

DO - 10.1186/1756-6606-6-33

M3 - Article (Academic Journal)

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JO - Molecular Brain

JF - Molecular Brain

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ER -

Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome

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