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What Have Slow Progressors Taught Us About T1D—Mind the Gap!

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What Have Slow Progressors Taught Us About T1D—Mind the Gap! / Gillespie, Kathleen M.; Long, Anna E.

In: Current diabetes reports, Vol. 19, 99, 01.10.2019.

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@article{d993d5b99b874c38a87e3b7ceaccad27,
title = "What Have Slow Progressors Taught Us About T1D—Mind the Gap!",
abstract = "Purpose of Review: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. Recent Findings: Birth cohort studies show that islet autoimmunity presents early in life and approximately 70{\%} of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. Summary: There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors.",
keywords = "Adult onset, Islet autoantibodies, Slow progression, Type 1 diabetes (T1D)",
author = "Gillespie, {Kathleen M.} and Long, {Anna E.}",
year = "2019",
month = "10",
day = "1",
doi = "10.1007/s11892-019-1219-1",
language = "English",
volume = "19",
journal = "Current diabetes reports",
issn = "1534-4827",
publisher = "Current Medicine Group",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - What Have Slow Progressors Taught Us About T1D—Mind the Gap!

AU - Gillespie, Kathleen M.

AU - Long, Anna E.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Purpose of Review: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. Recent Findings: Birth cohort studies show that islet autoimmunity presents early in life and approximately 70% of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. Summary: There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors.

AB - Purpose of Review: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. Recent Findings: Birth cohort studies show that islet autoimmunity presents early in life and approximately 70% of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. Summary: There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors.

KW - Adult onset

KW - Islet autoantibodies

KW - Slow progression

KW - Type 1 diabetes (T1D)

UR - http://www.scopus.com/inward/record.url?scp=85071978240&partnerID=8YFLogxK

U2 - 10.1007/s11892-019-1219-1

DO - 10.1007/s11892-019-1219-1

M3 - Review article

C2 - 31501992

AN - SCOPUS:85071978240

VL - 19

JO - Current diabetes reports

JF - Current diabetes reports

SN - 1534-4827

M1 - 99

ER -