What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis?: A systematic review

Helena Blakeway; V Van-de-Velde; V.B Allen; G Kravvas; L Palla; M.J Page; Carsten Flohr; R.B Weller; A.D Irvine; T McPherson; A Roberts; H.C Williams; N Reynolds; S.J Brown; Lavinia Paternoster; S.M Langan

doi:10.1111/bjd.18778

What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review

Helena Blakeway
, V Van-de-Velde
, V.B Allen
, G Kravvas
, L Palla
, M.J Page
, Carsten Flohr
, R.B Weller
, A.D Irvine
, T McPherson
, A Roberts
, H.C Williams
, N Reynolds
, S.J Brown
, Lavinia Paternoster
, S.M Langan

Research output: Contribution to journal › Article (Academic Journal) › peer-review

30 Citations (Scopus)

130 Downloads (Pure)

Abstract

Atopic dermatitis (AD), also known as eczema or atopic eczema, is a complex, multifactorial often debilitating disease.1 The prevalence of AD has risen rapidly, suggesting that environmental factors might be responsible for such changes.2 s.3 It is crucial to better understand the aetiology of AD to discover ways to reduce the personal and public health burden.

Original language	English
Number of pages	9
Journal	British Journal of Dermatology
Early online date	11 Feb 2020
DOIs	https://doi.org/10.1111/bjd.18778
Publication status	Published - 1 Sept 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Atopic dermatitis
atopic eczema
filaggrin
FLG
exposure
gene‐environment interaction

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10.1111/bjd.18778

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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

Blakeway, H., Van-de-Velde, V., Allen, V. B., Kravvas, G., Palla, L., Page, M. J., Flohr, C., Weller, R. B., Irvine, A. D., McPherson, T., Roberts, A., Williams, H. C., Reynolds, N., Brown, S. J., Paternoster, L., & Langan, S. M. (2020). What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review. British Journal of Dermatology. https://doi.org/10.1111/bjd.18778

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abstract = "Atopic dermatitis (AD), also known as eczema or atopic eczema, is a complex, multifactorial often debilitating disease.1 The prevalence of AD has risen rapidly, suggesting that environmental factors might be responsible for such changes.2 s.3 It is crucial to better understand the aetiology of AD to discover ways to reduce the personal and public health burden.",

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Blakeway, H, Van-de-Velde, V, Allen, VB, Kravvas, G, Palla, L, Page, MJ, Flohr, C, Weller, RB, Irvine, AD, McPherson, T, Roberts, A, Williams, HC, Reynolds, N, Brown, SJ, Paternoster, L & Langan, SM 2020, 'What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review', British Journal of Dermatology. https://doi.org/10.1111/bjd.18778

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AU - Blakeway, Helena

AU - Van-de-Velde, V

AU - Allen, V.B

AU - Kravvas, G

AU - Palla, L

AU - Page, M.J

AU - Flohr, Carsten

AU - Weller, R.B

AU - Irvine, A.D

AU - McPherson, T

AU - Roberts, A

AU - Williams, H.C

AU - Reynolds, N

AU - Brown, S.J

AU - Paternoster, Lavinia

AU - Langan, S.M

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AB - Atopic dermatitis (AD), also known as eczema or atopic eczema, is a complex, multifactorial often debilitating disease.1 The prevalence of AD has risen rapidly, suggesting that environmental factors might be responsible for such changes.2 s.3 It is crucial to better understand the aetiology of AD to discover ways to reduce the personal and public health burden.

KW - Atopic dermatitis

KW - atopic eczema

KW - filaggrin

KW - FLG

KW - exposure

KW - gene‐environment interaction

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DO - 10.1111/bjd.18778

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