Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.
|Translated title of the contribution||What's the point of the type III secretion system needle?|
|Pages (from-to)||6507 - 6513|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - May 2008|