When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study

Lauren E Cain; Roger Logan; James M Robins; Jonathan A C Sterne; Caroline Sabin; Loveleen Bansi; Amy Justice; Joseph Goulet; Ard van Sighem; Frank de Wolf; Heiner C Bucher; Viktor von Wyl; Anna Esteve; Jordi Casabona; Julia del Amo; Santiago Moreno; Remonie Seng; Laurence Meyer; Santiago Perez-Hoyos; Roberto Muga; Sara Lodi; Emilie Lanoy; Dominique Costagliola; Miguel A Hernan; HIV-CAUSAL Collaboration

doi:10.7326/0003-4819-154-8-201104190-00001

When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study

Lauren E Cain, Roger Logan, James M Robins, Jonathan A C Sterne, Caroline Sabin, Loveleen Bansi, Amy Justice, Joseph Goulet, Ard van Sighem, Frank de Wolf, Heiner C Bucher, Viktor von Wyl, Anna Esteve, Jordi Casabona, Julia del Amo, Santiago Moreno, Remonie Seng, Laurence Meyer, Santiago Perez-Hoyos, Roberto MugaSara Lodi, Emilie Lanoy, Dominique Costagliola, Miguel A Hernan, HIV-CAUSAL Collaboration

Research output: Contribution to journal › Article (Academic Journal) › peer-review

196 Citations (Scopus)

Abstract

Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate.

Original language	English
Pages (from-to)	509-515
Number of pages	7
Journal	Annals of Internal Medicine
Volume	154
Issue number	8
DOIs	https://doi.org/10.7326/0003-4819-154-8-201104190-00001
Publication status	Published - 19 Apr 2011

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http://annals.org/article.aspx?articleid=746932

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ART-CC: Prognosis of HIV-infected patients treated with ART
Sterne, J. A. C., Ingle, S. M. & May, M. T.
1/02/12 → 1/02/15
Project: Research
THE IMPACT OF HIGHLY EFFECTIVE ANTIRETROVIRAL THERAPY: MONITORING AND MODELLING BENEFIT AND HARM
Sterne, J. A. C.
1/02/02 → 1/02/08
Project: Research

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Cain, L. E., Logan, R., Robins, J. M., Sterne, J. A. C., Sabin, C., Bansi, L., Justice, A., Goulet, J., van Sighem, A., de Wolf, F., Bucher, H. C., von Wyl, V., Esteve, A., Casabona, J., del Amo, J., Moreno, S., Seng, R., Meyer, L., Perez-Hoyos, S., ... HIV-CAUSAL Collaboration (2011). When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Annals of Internal Medicine, 154(8), 509-515. https://doi.org/10.7326/0003-4819-154-8-201104190-00001

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title = "When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study",

abstract = "Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate.",

author = "Cain, {Lauren E} and Roger Logan and Robins, {James M} and Sterne, {Jonathan A C} and Caroline Sabin and Loveleen Bansi and Amy Justice and Joseph Goulet and {van Sighem}, Ard and {de Wolf}, Frank and Bucher, {Heiner C} and {von Wyl}, Viktor and Anna Esteve and Jordi Casabona and {del Amo}, Julia and Santiago Moreno and Remonie Seng and Laurence Meyer and Santiago Perez-Hoyos and Roberto Muga and Sara Lodi and Emilie Lanoy and Dominique Costagliola and Hernan, {Miguel A} and {HIV-CAUSAL Collaboration}",

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doi = "10.7326/0003-4819-154-8-201104190-00001",

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Cain, LE, Logan, R, Robins, JM, Sterne, JAC, Sabin, C, Bansi, L, Justice, A, Goulet, J, van Sighem, A, de Wolf, F, Bucher, HC, von Wyl, V, Esteve, A, Casabona, J, del Amo, J, Moreno, S, Seng, R, Meyer, L, Perez-Hoyos, S, Muga, R, Lodi, S, Lanoy, E, Costagliola, D, Hernan, MA & HIV-CAUSAL Collaboration 2011, 'When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study', Annals of Internal Medicine, vol. 154, no. 8, pp. 509-515. https://doi.org/10.7326/0003-4819-154-8-201104190-00001

When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. / Cain, Lauren E; Logan, Roger; Robins, James M et al.

In: Annals of Internal Medicine, Vol. 154, No. 8, 19.04.2011, p. 509-515.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study

AU - Cain, Lauren E

AU - Logan, Roger

AU - Robins, James M

AU - Sterne, Jonathan A C

AU - Sabin, Caroline

AU - Bansi, Loveleen

AU - Justice, Amy

AU - Goulet, Joseph

AU - van Sighem, Ard

AU - de Wolf, Frank

AU - Bucher, Heiner C

AU - von Wyl, Viktor

AU - Esteve, Anna

AU - Casabona, Jordi

AU - del Amo, Julia

AU - Moreno, Santiago

AU - Seng, Remonie

AU - Meyer, Laurence

AU - Perez-Hoyos, Santiago

AU - Muga, Roberto

AU - Lodi, Sara

AU - Lanoy, Emilie

AU - Costagliola, Dominique

AU - Hernan, Miguel A

AU - HIV-CAUSAL Collaboration

PY - 2011/4/19

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N2 - Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate.

AB - Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate.

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DO - 10.7326/0003-4819-154-8-201104190-00001

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VL - 154

SP - 509

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JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 8

ER -

When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study

Abstract

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Projects

ART-CC: Prognosis of HIV-infected patients treated with ART

THE IMPACT OF HIGHLY EFFECTIVE ANTIRETROVIRAL THERAPY: MONITORING AND MODELLING BENEFIT AND HARM

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