Which treatment is most effective for patients with patellofemoral pain? A protocol for a living systematic review including network meta-analysis

Marinus Winters, Sinead Holden, Bill Vicenzino, Nicky Welton, Deborah Caldwell, Carolina Byrne Lura, Adam Weir, Michael Skovdal Rathleff

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)
111 Downloads (Pure)

Abstract

Introduction Patellofemoral pain (PFP) affects 1 in every 14 adults. Many treatments for PFP have been evaluated, but the comparative effectiveness of all available treatments has never been examined. Network meta-analysis is the only design to study the comparative effectiveness of all available treatments in one synthesis. This protocol describes the methods for a systematic review including network meta-analysis, to assess which treatment is most likely to be effective for patients with PFP.

Methods and analysis The primary outcome measures of this network meta-analysis are the global rating of change scale at 6-12 weeks, 13 – 52 weeks and >52 weeks. The secondary outcome measures are patient-rated pain scales at 6-12 weeks, 13 – 52 weeks and >52 weeks. Completed published and unpublished randomised controlled trials with full text reports are eligible for inclusion. We will search EMbase, Pubmed (including MEDLINE), CENTRAL, Scopus, Web of Science, and CINAHL, SPORTDiscus, OpenGrey, Worldcat, Conference Proceedings and multiple trial registers for relevant reports. Two researchers will appraise the study eligibility and perform data extraction. Risk of bias will be assessed with the Cochrane Risk of Bias Tool v.2.0.
Bayesian network meta-analyses will be constructed for global rating of change scale and patientrated pain. Consistency between direct and indirect comparisons will be assessed. Between study variability will be explored and a threshold analysis for the credibility of the network meta-analyses’ conclusions will be performed.

Ethics and dissemination Ethical approval is not required, as this study will be based on published data. The study commenced at 1 February 2018 and its expected completion date is 15 January 2019. Full publication of the work will be sought in an international peer-reviewed journal, as well as translational articles to disseminate the work to clinical practitioners.

PROSPERO registration number: CRD42018079502
Original languageEnglish
Article numbere022920
Number of pages7
JournalBMJ Open
Volume8
Issue number11
Early online date18 Nov 2018
DOIs
Publication statusPublished - Nov 2018

Keywords

  • Patellofemoral pain
  • knee cap
  • network meta-analysis
  • evidence synthesis
  • ranking

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