Why do hippocampal mossy cells matter?: It depends on the frequency and context

Katarina Kolaric; Christina  Strauch; Yingxin Li; Sasha M Woods; Marinho A Lopes; Natasha  Sivarajah; Catia M Teixeira; Jason  Lerch; Paul W Frankland; Mark Henkelman; Zuner A Bortolotto; Clea Warburton; Zafar I Bashir; Denise Manahan Vaughan; Denize Atan

doi:10.1101/2021.12.04.467951

Why do hippocampal mossy cells matter? It depends on the frequency and context

Katarina Kolaric, Christina Strauch, Yingxin Li, Sasha M Woods, Marinho A Lopes, Natasha Sivarajah, Catia M Teixeira, Jason Lerch, Paul W Frankland, Mark Henkelman, Zuner A Bortolotto, Clea Warburton, Zafar I Bashir, Denise Manahan Vaughan, Denize Atan^*

^*Corresponding author for this work

Research output: Working paper › Preprint

Abstract

The discrimination of similar episodes and places, and their representation as distinct memories, depend on a process called pattern separation that relies on the circuitry of the hippocampal dentate gyrus (DG). Mossy cells (MCs) are key neurons in the circuitry, but how they influence DG network dynamics, function, and seizure risk has not been fully elucidated. We found the net impact of MCs was inhibitory at physiological frequencies connected with learning and behaviour, and their absence associated with deficits in pattern separation and spatial memory; at higher frequencies, their net impact was excitatory, and their absence protected against seizures. Thus, MCs influence DG outputs in a highly dynamic manner that varies with frequency and context.

One-Sentence Summary Hippocampal mossy cells are required for learning and memory; but their absence protects against seizures.

Original language	English
Publisher	bioRxiv.org
Pages	1-30
Number of pages	30
DOIs	https://doi.org/10.1101/2021.12.04.467951
Publication status	Submitted - 6 Dec 2021

Research Groups and Themes

Brain and Behaviour
Memory

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Cite this

Kolaric, K., Strauch, C., Li, Y., Woods, S. M., Lopes, M. A., Sivarajah, N., Teixeira, C. M., Lerch, J., Frankland, P. W., Henkelman, M., Bortolotto, Z. A., Warburton, C., Bashir, Z. I., Vaughan, D. M., & Atan, D. (2021). Why do hippocampal mossy cells matter? It depends on the frequency and context. (pp. 1-30). bioRxiv.org. https://doi.org/10.1101/2021.12.04.467951

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AU - Lopes, Marinho A

AU - Sivarajah, Natasha

AU - Teixeira, Catia M

AU - Lerch, Jason

AU - Frankland, Paul W

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