With unprotected amino acids to tetrazolo peptidomimetics

Rudrakshula Madhavachary, Qian Wang, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Abstract

Here we describe the direct usage of C,N-unprotected amino acids in Ugi-tetrazole reactions to produce a novel class of acid-tetrazole compounds. Surprisingly, only the tetrazole Ugi product is found and not traces of other possible Ugi type reactions. Based on this reaction pathway we have designed the synthesis of novel tetrazole-peptidomimetics. A high level of structural diversity can be achieved using this isocyanide based multicomponent reaction (IMCR), providing a platform for the production of functionalized building blocks for novel bioactive molecules and nontraditional scaffolds which previously were not accessible.

Original languageEnglish
Pages (from-to)8549-8552
Number of pages4
JournalChemical Communications
Volume53
Issue number61
Early online date12 Jul 2017
DOIs
Publication statusE-pub ahead of print - 12 Jul 2017

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