TY - JOUR
T1 - Working-for-Food Behaviors
T2 - A Preclinical Study in Prader-Willi Mutant Mice
AU - Lassi, Glenda
AU - Maggi, Silvia
AU - Balzani, Edoardo
AU - Cosentini, Ilaria
AU - Garcia-Garcia, Celina
AU - Tucci, Valter
N1 - Copyright © 2016 by the Genetics Society of America.
PY - 2016/11
Y1 - 2016/11
N2 - Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant mice show a significant delay compared to wild-type littermate controls in responding to both hour-scale and seconds-to-minutes-scale time intervals. This timing shift in mutant mice is associated with better performance in the working-for-food task, and results in better decision making in these mutant mice. The results of our study reveal a novel aspect of the organization of feeding behavior, and advance the understanding of the interplay between the metabolic functions and cognitive mechanisms of PWS.
AB - Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant mice show a significant delay compared to wild-type littermate controls in responding to both hour-scale and seconds-to-minutes-scale time intervals. This timing shift in mutant mice is associated with better performance in the working-for-food task, and results in better decision making in these mutant mice. The results of our study reveal a novel aspect of the organization of feeding behavior, and advance the understanding of the interplay between the metabolic functions and cognitive mechanisms of PWS.
KW - Journal Article
U2 - 10.1534/genetics.116.192286
DO - 10.1534/genetics.116.192286
M3 - Article (Academic Journal)
C2 - 27672097
SN - 0016-6731
VL - 204
SP - 1129
EP - 1138
JO - Genetics
JF - Genetics
IS - 3
ER -