Wound Healing Insights from Flies and Fish

All organisms from single-cell amoebae through to Homo sapiens have evolved strategies for repairing wounds as an essential homeostatic mechanism for rebuilding their outer barrier layers after damage. In multicellular animals, this outer barrier layer is the skin, and, for more than a century, scientists have been attempting to unravel the mechanisms underpinning skin repair because of its clear clinical relevance to pathologies that range from chronic nonhealing wounds, through to excessive scarring. Most of these studies have been in rabbits and rodents, or in in vitro scratch wound models, but in the last decades, two newcomer model organisms to wound healing studies—flies and fish—have brought genetic tractability and unparalleled opportunities for live imaging to the field. These two models are complementary to one another, and to mouse and in vitro approaches, and thus offer different insights into various aspects of the wound repair process.