Wound repair: a showcase for cell plasticity and migration

Tanya J Shaw, Paul Martin

Research output: Contribution to journalSpecial issue (Academic Journal)peer-review

82 Citations (Scopus)
325 Downloads (Pure)

Abstract

A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response – all of these cells are ‘dynamic’ in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.
Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume42
Early online date14 Apr 2016
DOIs
Publication statusPublished - Oct 2016

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