Wound repair: a showcase for cell plasticity and migration

Tanya J Shaw; Paul Martin

doi:10.1016/j.ceb.2016.04.001

Wound repair: a showcase for cell plasticity and migration

Tanya J Shaw, Paul Martin

Research output: Contribution to journal › Special issue (Academic Journal) › peer-review

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Abstract

A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response – all of these cells are ‘dynamic’ in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Current Opinion in Cell Biology
Volume	42
Early online date	14 Apr 2016
DOIs	https://doi.org/10.1016/j.ceb.2016.04.001
Publication status	Published - Oct 2016

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via ELSEVIER at http://www.sciencedirect.com/science/article/pii/S095506741630076X?via%3Dihub#ack0005. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 15.1 MBLicence: CC BY-NC-ND

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Statistical modelling of in vivo immune response dynamics in zebrafish to multiple stimuli
Martin, P. B. (Principal Investigator)
11/11/13 → 11/11/16
Project: Research
Modelling of wound repair and inflammation in the Drosophila embryo
Martin, P. B. (Principal Investigator)
31/12/12 → 30/12/18
Project: Research

Cite this

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title = "Wound repair: a showcase for cell plasticity and migration",

abstract = "A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response – all of these cells are {\textquoteleft}dynamic{\textquoteright} in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.",

author = "Shaw, {Tanya J} and Paul Martin",

year = "2016",

month = oct,

doi = "10.1016/j.ceb.2016.04.001",

language = "English",

volume = "42",

pages = "29--37",

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T2 - a showcase for cell plasticity and migration

AU - Shaw, Tanya J

AU - Martin, Paul

PY - 2016/10

Y1 - 2016/10

N2 - A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response – all of these cells are ‘dynamic’ in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.

AB - A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response – all of these cells are ‘dynamic’ in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.

U2 - 10.1016/j.ceb.2016.04.001

DO - 10.1016/j.ceb.2016.04.001

M3 - Special issue (Academic Journal)

C2 - 27085790

SN - 0955-0674

VL - 42

SP - 29

EP - 37

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Wound repair: a showcase for cell plasticity and migration

Abstract

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Projects

Statistical modelling of in vivo immune response dynamics in zebrafish to multiple stimuli

Modelling of wound repair and inflammation in the Drosophila embryo

Cite this