Wound repair at a glance

TJ Shaw, P Martin

Research output: Contribution to journalArticle (Academic Journal)peer-review

441 Citations (Scopus)

Abstract

Wound repair is an essential physiological process that is important for tissue homeostasis, but it can be impaired in disease and contributes to numerous pathologies. The wound healing process, particularly in skin, has been well characterised histologically in studies extending back more than 100 years. Skin is a complex tissue (reviewed by Kanitakis, 2002), and thus a `full-thickness' wound results in damage to many structures, cell layers and lineages, including (from the outside in): the epidermal keratinocyte layer (the body's barrier to the outside world), together with associated epidermal appendages such as hair follicles and sweat glands; the basement membrane (BM) that underlies the epidermis; and the dermis, which is an intricate structure that consists of fibroblasts, extracellular matrix (ECM), nerves, and blood and lymphatic vessels. A wound also causes damage at the level of individual cells (McNeil and Kirchhausen, 2005).
Translated title of the contributionWound repair at a glance
Original languageEnglish
Pages (from-to)3209 - 3213
Number of pages5
JournalJournal of Cell Science
Volume122 (18)
DOIs
Publication statusPublished - Sep 2009

Bibliographical note

Other: Part of a minfocus on collective cell migration. First published online 2nd September 2009

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