Abstract
Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.
Original language | English |
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Pages (from-to) | 153-5 |
Number of pages | 3 |
Journal | Molecular Cell |
Volume | 37 |
Issue number | 2 |
DOIs | |
Publication status | Published - 29 Jan 2010 |
Keywords
- Antineoplastic Agents
- Apoptosis
- Genes, Wilms Tumor
- Humans
- Mitochondrial Proteins
- Neoplasms
- Serine Endopeptidases
- Stress, Physiological
- WT1 Proteins
- Comment
- Journal Article