WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi, Nicholas D Hastie

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)


Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Original languageEnglish
Pages (from-to)153-5
Number of pages3
JournalMolecular Cell
Issue number2
Publication statusPublished - 29 Jan 2010


  • Antineoplastic Agents
  • Apoptosis
  • Genes, Wilms Tumor
  • Humans
  • Mitochondrial Proteins
  • Neoplasms
  • Serine Endopeptidases
  • Stress, Physiological
  • WT1 Proteins
  • Comment
  • Journal Article


Dive into the research topics of 'WT1 the oncogene: a tale of death and HtrA'. Together they form a unique fingerprint.

Cite this