WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi, Nicholas D Hastie

Research output: Contribution to journalArticle (Academic Journal)peer-review

9 Citations (Scopus)

Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Original languageEnglish
Pages (from-to)153-5
Number of pages3
JournalMolecular Cell
Volume37
Issue number2
DOIs
Publication statusPublished - 29 Jan 2010

Keywords

  • Antineoplastic Agents
  • Apoptosis
  • Genes, Wilms Tumor
  • Humans
  • Mitochondrial Proteins
  • Neoplasms
  • Serine Endopeptidases
  • Stress, Physiological
  • WT1 Proteins
  • Comment
  • Journal Article

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