WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi; Nicholas D Hastie

doi:10.1016/j.molcel.2010.01.010

WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi, Nicholas D Hastie

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Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Original language	English
Pages (from-to)	153-5
Number of pages	3
Journal	Molecular Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2010.01.010
Publication status	Published - 29 Jan 2010

Keywords

Antineoplastic Agents
Apoptosis
Genes, Wilms Tumor
Humans
Mitochondrial Proteins
Neoplasms
Serine Endopeptidases
Stress, Physiological
WT1 Proteins
Comment
Journal Article

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title = "WT1 the oncogene: a tale of death and HtrA",

abstract = "Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.",

keywords = "Antineoplastic Agents, Apoptosis, Genes, Wilms Tumor, Humans, Mitochondrial Proteins, Neoplasms, Serine Endopeptidases, Stress, Physiological, WT1 Proteins, Comment, Journal Article",

author = "Abdelkader Essafi and Hastie, {Nicholas D}",

year = "2010",

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journal = "Molecular Cell",

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T1 - WT1 the oncogene

T2 - a tale of death and HtrA

AU - Essafi, Abdelkader

AU - Hastie, Nicholas D

PY - 2010/1/29

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N2 - Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

AB - Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

KW - Antineoplastic Agents

KW - Apoptosis

KW - Genes, Wilms Tumor

KW - Humans

KW - Mitochondrial Proteins

KW - Neoplasms

KW - Serine Endopeptidases

KW - Stress, Physiological

KW - WT1 Proteins

KW - Comment

KW - Journal Article

U2 - 10.1016/j.molcel.2010.01.010

DO - 10.1016/j.molcel.2010.01.010

M3 - Article (Academic Journal)

C2 - 20122396

SN - 1097-2765

VL - 37

SP - 153

EP - 155

JO - Molecular Cell

JF - Molecular Cell

IS - 2

ER -

WT1 the oncogene: a tale of death and HtrA

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Keywords

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