Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

Tatiane Mieko de Meneses Fujii, Patrícia Silva Jacob, Monica Yamada, Maria Carolina Borges, Marina Maintinguer Norde, Lucas Carminatti Pantaleão, Daniela Moura de Oliveira, Julio Tirapegui, Inar Alves de Castro, Primavera Borelli, Ricardo Ambrósio Fock, Marcelo Macedo Rogero

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)

Abstract

To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.

Original languageEnglish
Pages (from-to)967-76
Number of pages10
JournalInternational Journal of Food Science and Technology
Volume65
Issue number8
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Adipose Tissue
  • Animals
  • Blood Glucose
  • Cholesterol
  • Diet, High-Fat
  • Ilex paraguariensis
  • Inflammation
  • Insulin
  • Insulin Resistance
  • Liver
  • Male
  • Muscles
  • NF-kappa B
  • Obesity
  • Phosphorylation
  • Phytotherapy
  • Plant Extracts
  • Proto-Oncogene Proteins c-akt
  • Rats, Wistar
  • Weight Gain

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