Abstract
To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.
Original language | English |
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Pages (from-to) | 967-76 |
Number of pages | 10 |
Journal | International Journal of Food Science and Technology |
Volume | 65 |
Issue number | 8 |
DOIs | |
Publication status | Published - Dec 2014 |
Keywords
- Adipose Tissue
- Animals
- Blood Glucose
- Cholesterol
- Diet, High-Fat
- Ilex paraguariensis
- Inflammation
- Insulin
- Insulin Resistance
- Liver
- Male
- Muscles
- NF-kappa B
- Obesity
- Phosphorylation
- Phytotherapy
- Plant Extracts
- Proto-Oncogene Proteins c-akt
- Rats, Wistar
- Weight Gain