Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

Tatiane Mieko de Meneses Fujii; Patrícia Silva Jacob; Monica Yamada; Maria Carolina Borges; Marina Maintinguer Norde; Lucas Carminatti Pantaleão; Daniela Moura de Oliveira; Julio Tirapegui; Inar Alves de Castro; Primavera Borelli; Ricardo Ambrósio Fock; Marcelo Macedo Rogero

doi:10.3109/09637486.2014.945153

Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

Tatiane Mieko de Meneses Fujii, Patrícia Silva Jacob, Monica Yamada, Maria Carolina Borges, Marina Maintinguer Norde, Lucas Carminatti Pantaleão, Daniela Moura de Oliveira, Julio Tirapegui, Inar Alves de Castro, Primavera Borelli, Ricardo Ambrósio Fock, Marcelo Macedo Rogero

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.

Original language	English
Pages (from-to)	967-76
Number of pages	10
Journal	International Journal of Food Science and Technology
Volume	65
Issue number	8
DOIs	https://doi.org/10.3109/09637486.2014.945153
Publication status	Published - Dec 2014

Keywords

Adipose Tissue
Animals
Blood Glucose
Cholesterol
Diet, High-Fat
Ilex paraguariensis
Inflammation
Insulin
Insulin Resistance
Liver
Male
Muscles
NF-kappa B
Obesity
Phosphorylation
Phytotherapy
Plant Extracts
Proto-Oncogene Proteins c-akt
Rats, Wistar
Weight Gain

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de Meneses Fujii, T. M., Jacob, P. S., Yamada, M., Borges, M. C., Norde, M. M., Pantaleão, L. C., de Oliveira, D. M., Tirapegui, J., de Castro, I. A., Borelli, P., Fock, R. A., & Rogero, M. M. (2014). Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet. International Journal of Food Science and Technology, 65(8), 967-76. https://doi.org/10.3109/09637486.2014.945153

@article{567ee7d3df32488eb6a70d227a80b7d2,

title = "Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet",

abstract = "To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.",

keywords = "Adipose Tissue, Animals, Blood Glucose, Cholesterol, Diet, High-Fat, Ilex paraguariensis, Inflammation, Insulin, Insulin Resistance, Liver, Male, Muscles, NF-kappa B, Obesity, Phosphorylation, Phytotherapy, Plant Extracts, Proto-Oncogene Proteins c-akt, Rats, Wistar, Weight Gain",

author = "{de Meneses Fujii}, {Tatiane Mieko} and Jacob, {Patr{\'i}cia Silva} and Monica Yamada and Borges, {Maria Carolina} and Norde, {Marina Maintinguer} and Pantale{\~a}o, {Lucas Carminatti} and {de Oliveira}, {Daniela Moura} and Julio Tirapegui and {de Castro}, {Inar Alves} and Primavera Borelli and Fock, {Ricardo Ambr{\'o}sio} and Rogero, {Marcelo Macedo}",

year = "2014",

month = dec,

doi = "10.3109/09637486.2014.945153",

language = "English",

volume = "65",

pages = "967--76",

journal = "International Journal of Food Science and Technology",

issn = "0950-5423",

publisher = "Wiley-Blackwell",

number = "8",

}

de Meneses Fujii, TM, Jacob, PS, Yamada, M, Borges, MC, Norde, MM, Pantaleão, LC, de Oliveira, DM, Tirapegui, J, de Castro, IA, Borelli, P, Fock, RA & Rogero, MM 2014, 'Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet', International Journal of Food Science and Technology, vol. 65, no. 8, pp. 967-76. https://doi.org/10.3109/09637486.2014.945153

Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet. / de Meneses Fujii, Tatiane Mieko; Jacob, Patrícia Silva; Yamada, Monica et al.

In: International Journal of Food Science and Technology, Vol. 65, No. 8, 12.2014, p. 967-76.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

AU - de Meneses Fujii, Tatiane Mieko

AU - Jacob, Patrícia Silva

AU - Yamada, Monica

AU - Borges, Maria Carolina

AU - Norde, Marina Maintinguer

AU - Pantaleão, Lucas Carminatti

AU - de Oliveira, Daniela Moura

AU - Tirapegui, Julio

AU - de Castro, Inar Alves

AU - Borelli, Primavera

AU - Fock, Ricardo Ambrósio

AU - Rogero, Marcelo Macedo

PY - 2014/12

Y1 - 2014/12

N2 - To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.

AB - To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.

KW - Adipose Tissue

KW - Animals

KW - Blood Glucose

KW - Cholesterol

KW - Diet, High-Fat

KW - Ilex paraguariensis

KW - Inflammation

KW - Insulin

KW - Insulin Resistance

KW - Liver

KW - Male

KW - Muscles

KW - NF-kappa B

KW - Obesity

KW - Phosphorylation

KW - Phytotherapy

KW - Plant Extracts

KW - Proto-Oncogene Proteins c-akt

KW - Rats, Wistar

KW - Weight Gain

U2 - 10.3109/09637486.2014.945153

DO - 10.3109/09637486.2014.945153

M3 - Article (Academic Journal)

C2 - 25088791

VL - 65

SP - 967

EP - 976

JO - International Journal of Food Science and Technology

JF - International Journal of Food Science and Technology

SN - 0950-5423

IS - 8

ER -

Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet

Abstract

Keywords

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