Young Adult ADHD Symptoms in the General Population and Neurocognitive Impairment

Sharifah Shameem Agha; Lucy Riglin; Rhian Carbury; Rachel Blakey; Amy Shakeshaft; Ajay K Thapar; Kate Tilling; Stephan Collishaw; Evie Stergiakouli; Anita Thapar; Kate Langley

doi:10.1177/10870547231201870

Young Adult ADHD Symptoms in the General Population and Neurocognitive Impairment

Sharifah Shameem Agha, Lucy Riglin, Rhian Carbury, Rachel Blakey, Amy Shakeshaft, Ajay K Thapar, Kate Tilling, Stephan Collishaw, Evie Stergiakouli, Anita Thapar, Kate Langley

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

Abstract

OBJECTIVE: Neurocognitive impairments are associated with child and adult ADHD in clinical settings. However, it is unknown whether adult ADHD symptoms in the general population are associated with the same pattern of cognitive impairment. We examined this using a prospective, population-based cohort spanning birth to age 25 years.

METHODS: We examined associations between self-reported adult ADHD symptoms and cognitive task performance (attention and response inhibition) in adulthood and childhood.

RESULTS: Self-rated ADHD symptoms at age 25 were associated with poorer performance in age 25 cognitive tasks capturing ADHD-related functioning (attention B = -0.03, 95% CI [0.05, -0.01], p = .005; response inhibition B = -0.03, 95% CI [-0.05, -0.01], p = .002).

CONCLUSIONS: Neurocognitive impairments linked to adult ADHD symptoms in the general population, are similar to those found in people with childhood ADHD symptoms and are consistent with findings in adult ADHD clinical samples.

Original language	English
Pages (from-to)	89-98
Number of pages	10
Journal	Journal of Attention Disorders
Volume	28
Issue number	1
DOIs	https://doi.org/10.1177/10870547231201870
Publication status	Published - 1 Jan 2024

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Sharifah Shameem Agha, Lucy Riglin, Kate Langley and Anita Thapar will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website ( www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). The measures used in the paper were specifically funded by the Wellcome Trust (204895/Z/16/Z). RB and AS are employed on a grant funded by the Wellcome Trust (204895/Z/16/Z) for which funding was acquired by AT, KT and ES. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. ES, KT and RB work in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_00011/1 and MC_UU_00011/3). LR is funded by the Wolfson Foundation. This work was supported by the Wolfson Centre for Young People’s Mental Health, established with support from the Wolfson Foundation.

Publisher Copyright:
© The Author(s) 2023.

Research Groups and Themes

Bristol Population Health Science Institute

Keywords

Adult
Humans
Attention
Attention Deficit Disorder with Hyperactivity/diagnosis
Prospective Studies
neurocognitive impairment
ALSPAC

Access to Document

10.1177/10870547231201870Licence: CC BY

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Persistent link

Rework of IEU 2 Tilling Programme
Tilling, K. M. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research
IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

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title = "Young Adult ADHD Symptoms in the General Population and Neurocognitive Impairment",

abstract = "OBJECTIVE: Neurocognitive impairments are associated with child and adult ADHD in clinical settings. However, it is unknown whether adult ADHD symptoms in the general population are associated with the same pattern of cognitive impairment. We examined this using a prospective, population-based cohort spanning birth to age 25 years.METHODS: We examined associations between self-reported adult ADHD symptoms and cognitive task performance (attention and response inhibition) in adulthood and childhood.RESULTS: Self-rated ADHD symptoms at age 25 were associated with poorer performance in age 25 cognitive tasks capturing ADHD-related functioning (attention B = -0.03, 95\% CI [0.05, -0.01], p = .005; response inhibition B = -0.03, 95\% CI [-0.05, -0.01], p = .002).CONCLUSIONS: Neurocognitive impairments linked to adult ADHD symptoms in the general population, are similar to those found in people with childhood ADHD symptoms and are consistent with findings in adult ADHD clinical samples.",

keywords = "Adult, Humans, Attention, Attention Deficit Disorder with Hyperactivity/diagnosis, Prospective Studies, neurocognitive impairment, ALSPAC",

author = "Agha, \{Sharifah Shameem\} and Lucy Riglin and Rhian Carbury and Rachel Blakey and Amy Shakeshaft and Thapar, \{Ajay K\} and Kate Tilling and Stephan Collishaw and Evie Stergiakouli and Anita Thapar and Kate Langley",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Sharifah Shameem Agha, Lucy Riglin, Kate Langley and Anita Thapar will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website ( www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). The measures used in the paper were specifically funded by the Wellcome Trust (204895/Z/16/Z). RB and AS are employed on a grant funded by the Wellcome Trust (204895/Z/16/Z) for which funding was acquired by AT, KT and ES. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. ES, KT and RB work in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC\_UU\_00011/1 and MC\_UU\_00011/3). LR is funded by the Wolfson Foundation. This work was supported by the Wolfson Centre for Young People{\textquoteright}s Mental Health, established with support from the Wolfson Foundation. Publisher Copyright: {\textcopyright} The Author(s) 2023.",

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doi = "10.1177/10870547231201870",

language = "English",

volume = "28",

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T1 - Young Adult ADHD Symptoms in the General Population and Neurocognitive Impairment

AU - Agha, Sharifah Shameem

AU - Riglin, Lucy

AU - Carbury, Rhian

AU - Blakey, Rachel

AU - Shakeshaft, Amy

AU - Thapar, Ajay K

AU - Tilling, Kate

AU - Collishaw, Stephan

AU - Stergiakouli, Evie

AU - Thapar, Anita

AU - Langley, Kate

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Sharifah Shameem Agha, Lucy Riglin, Kate Langley and Anita Thapar will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website ( www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). The measures used in the paper were specifically funded by the Wellcome Trust (204895/Z/16/Z). RB and AS are employed on a grant funded by the Wellcome Trust (204895/Z/16/Z) for which funding was acquired by AT, KT and ES. For the purpose of Open Access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. ES, KT and RB work in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_00011/1 and MC_UU_00011/3). LR is funded by the Wolfson Foundation. This work was supported by the Wolfson Centre for Young People’s Mental Health, established with support from the Wolfson Foundation. Publisher Copyright: © The Author(s) 2023.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - OBJECTIVE: Neurocognitive impairments are associated with child and adult ADHD in clinical settings. However, it is unknown whether adult ADHD symptoms in the general population are associated with the same pattern of cognitive impairment. We examined this using a prospective, population-based cohort spanning birth to age 25 years.METHODS: We examined associations between self-reported adult ADHD symptoms and cognitive task performance (attention and response inhibition) in adulthood and childhood.RESULTS: Self-rated ADHD symptoms at age 25 were associated with poorer performance in age 25 cognitive tasks capturing ADHD-related functioning (attention B = -0.03, 95% CI [0.05, -0.01], p = .005; response inhibition B = -0.03, 95% CI [-0.05, -0.01], p = .002).CONCLUSIONS: Neurocognitive impairments linked to adult ADHD symptoms in the general population, are similar to those found in people with childhood ADHD symptoms and are consistent with findings in adult ADHD clinical samples.

AB - OBJECTIVE: Neurocognitive impairments are associated with child and adult ADHD in clinical settings. However, it is unknown whether adult ADHD symptoms in the general population are associated with the same pattern of cognitive impairment. We examined this using a prospective, population-based cohort spanning birth to age 25 years.METHODS: We examined associations between self-reported adult ADHD symptoms and cognitive task performance (attention and response inhibition) in adulthood and childhood.RESULTS: Self-rated ADHD symptoms at age 25 were associated with poorer performance in age 25 cognitive tasks capturing ADHD-related functioning (attention B = -0.03, 95% CI [0.05, -0.01], p = .005; response inhibition B = -0.03, 95% CI [-0.05, -0.01], p = .002).CONCLUSIONS: Neurocognitive impairments linked to adult ADHD symptoms in the general population, are similar to those found in people with childhood ADHD symptoms and are consistent with findings in adult ADHD clinical samples.

KW - Adult

KW - Humans

KW - Attention

KW - Attention Deficit Disorder with Hyperactivity/diagnosis

KW - Prospective Studies

KW - neurocognitive impairment

KW - ALSPAC

U2 - 10.1177/10870547231201870

DO - 10.1177/10870547231201870

M3 - Article (Academic Journal)

C2 - 37864348

SN - 1087-0547

VL - 28

SP - 89

EP - 98

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 1

ER -

Young Adult ADHD Symptoms in the General Population and Neurocognitive Impairment

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

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Projects

Rework of IEU 2 Tilling Programme

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Cite this