Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease

Joanna J Moss; Christina Hammond; Jon D Lane

doi:10.1007/s00418-020-01917-2

Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease

Joanna J Moss, Christina Hammond^*, Jon D Lane^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

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Abstract

In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effects of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders

Original language	English
Number of pages	16
Journal	Histochemistry and Cell Biology
DOIs	https://doi.org/10.1007/s00418-020-01917-2
Publication status	Published - 11 Sep 2020

Keywords

Autophagy
Zebrafish
Bone
Development
Tools

Access to Document

10.1007/s00418-020-01917-2

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KW - Zebrafish

KW - Bone

KW - Development

KW - Tools

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