Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease

Joanna J Moss, Christina Hammond*, Jon D Lane*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

15 Downloads (Pure)

Abstract

In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effects of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders
Original languageEnglish
Number of pages16
JournalHistochemistry and Cell Biology
DOIs
Publication statusPublished - 11 Sep 2020

Keywords

  • Autophagy
  • Zebrafish
  • Bone
  • Development
  • Tools

Fingerprint Dive into the research topics of 'Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease'. Together they form a unique fingerprint.

Cite this