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• Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce-Smiles Rearrangement of Benzanilides

  Abrams, R., Jesani, M. H., Browning, A. & Clayden, J., 8 Apr 2021, In: Angewandte Chemie - International Edition. 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • benzanilide
  • Amides
  • Lactams
  • Functional groups
  • Conformations
  2 Downloads (Pure)

• ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

  Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In: Acta Neuropathologica. 139, p. 485–502 18 p.

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  • diminazene aceturate
  • Amyloid
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Pathology
  112 Downloads (Pure)

• A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

  Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In: ACS Chemical Biology. 2020, 10 p.

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  • thiomarinol
  • Biosynthesis
  • Mupirocin
  • Acyl Carrier Protein
  • Starters
  13 Downloads (Pure)

• Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides

  Zieleniewski, F. M., Woolfson, D. N. & Clayden, J. P., 2 Sep 2020, In: Chemical Communications. (2020), 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • 2-aminoisobutyric acid
  • Peptides
  • Acids
  • Oligomers
  • Water
  50 Downloads (Pure)

• Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes

  Jeanneret, R. A., Johnson, S. E. & Galan, M. C., 26 Oct 2020, In: Journal of Organic Chemistry. (2020), 26 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycosylation
  • Stereoselectivity
  • Oligosaccharides
  • Carbohydrates

• Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates

  Doobary, S., Sedikides, A. T., Caldora, H. P., Poole, D. L. & Lennox, A. J. J., 13 Jan 2020, In: Angewandte Chemie - International Edition. 59, 3, p. 1155-1160 6 p.

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  • Alkenes
  • Olefins
  • Electrons
  • Substrates
  • Pharmacokinetics
  19 Citations (Scopus)

  168 Downloads (Pure)

• Enhanced sampling molecular dynamics simulations correctly predict the diverse activities of a series of stiff-stilbene G-quadruplex DNA ligands

  O'Hagan, M. P., Haldar, S., Morales, J. C., Mulholland, A. J. & Galan, M. C., 26 Nov 2020, In: Chemical Science. 12, 12 p., 1415-1426.

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  • Stilbenes
  • Molecular dynamics
  • Ligands
  • Sampling
  • DNA
  3 Downloads (Pure)

• Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds

  Millward, M. J., Ellis, E., Ward, J. W. & Clayden, J. P., 14 Dec 2020, In: Chemical Science. (2021), 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Hydantoins
  • Nitriles
  • Scaffolds
  • Anions
  • Urea
  16 Downloads (Pure)

• Mapping the multi-step mechanism of a photoredox catalyzed atom-transfer radical polymerization reaction by direct observation of the reactive intermediates

  Lewis-Borrell, L., Sneha, M., Bhattacherjee, A., Clark, I. P. & Orr-Ewing, A. J., 16 Apr 2020, In: Chemical Science. 11, 17, p. 4475-4481 7 p., 4475.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Atom transfer radical polymerization
  • Photocatalysts
  • Excited states
  • isoprene
  • Catalysis
  67 Downloads (Pure)

• Minimal manual input

  Heard, D. M. & Lennox, A. J. J., 3 Feb 2020, In: Nature Chemistry. 12, 2, p. 113-114 2 p.

  Research output: Contribution to journal › Article (Academic Journal)

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  • Organic Chemistry
  • Industry
  73 Downloads (Pure)

• Odd–even alternations in helical propensity of a homologous series of hydrocarbons

  Pradeilles, J. A., Zhong, S., Baglyas, M., Tarczay, G., Butts, C. P., Myers, E. L. & Aggarwal, V. K., 2 Mar 2020, In: Nature Chemistry. 12, p. 475-480 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Hydrocarbons
  • Chain length
  • Self assembled monolayers
  • Soft materials
  • Conformations
  43 Downloads (Pure)

• Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

  Henderson, A. S., Bower, J. F. & Galan, M. C., 29 Apr 2020, In: Organic and Biomolecular Chemistry. 18, 16, p. 3012-3016 5 p.

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  • carbene
  • carbenes
  • carbohydrates
  • ligands
  • Hydrosilylation
  9 Downloads (Pure)

• Solvent-dependent photochemical dynamics of a phenoxazine-based photoredox catalyst

  Sneha, M., Lewis-Borrell, L., Shchepanovska, D., Bhattacherjee, A., Tyler, J. L. & Orr-Ewing, A. J., 27 Aug 2020, In: Zeitschrift für Physikalische Chemie. 234, p. 1475 - 1494

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • phenoxazine
  • Excited states
  • catalysts
  • Catalysts
  • Ground state

• Stiff‐Stilbene Ligands Target G‐Quadruplex DNA and Exhibit Selective Anticancer and Antiparasitic Activity

  Galan, M. C., O'Hagan, M. P., Morales, J. C., Fisher, R. & Peñalver, P., 28 Feb 2020, (Accepted/In press) In: Chemistry - A European Journal.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Antiparasitic Agents
  • Ligands
  • DNA
  • HeLa Cells
  • Nucleic Acids
  88 Downloads (Pure)

• Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications

  Michel, S. E. S., Rogers, S. E., Briscoe, W. H. & Galan, M. C., 16 Nov 2020, In: ACS Applied Bio Materials. 3, p. 8075-8083 9 p., 11.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • thiols
  • swelling
  • collagens
  • viability
  • cells

• Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

  O'Hagan, M. P., Ramos-Soriano, J., Haldar, S., Sheikh, S., Morales, J. C., Mulholland, A. J. & Galan, M. C., 8 May 2020, In: Chemical Communications. 56, 38, p. 5186-5189 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • G-Quadruplexes
  • Ligands
  • DNA
  • Light
  • Toxicity
  8 Downloads (Pure)

• A biomimetic receptor for glucose

  Tromans, R. A., Carter, T. S., Chabanne, L., Crump, M. P., Li, H., Matlock, J. V., Orchard, M. G. & Davis, A. P., Jan 2019, In: Nature Chemistry. 11, 1, p. 52-56 5 p.

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  • glucose receptor
  • Biomimetics
  • Glucose
  • Substrates
  • Artificial Receptors
  77 Citations (Scopus)

  407 Downloads (Pure)

• A Natural Diels-Alder Biocatalyst Enables Efficient [4 + 2] Cycloaddition Under Harsh Reaction Conditions

  Marsh, C. O., Lees, N. R., Han, L-C., Byrne, M. J., Mbatha, S. Z., Maschio, L., Pagden-Ratcliffe, S., Duke, P., Stach, J. E. M., Curnow, P., Willis, C. L. & Race, P. R., 25 Aug 2019, In: ChemCatChem. 6 p.

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  • Cycloaddition
  • cycloaddition
  • Biocatalysts
  • Organic solvents
  • Enzymes
  2 Citations (Scopus)

  82 Downloads (Pure)

• An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis

  Lees, N. R., Han, L-C., Byrne, M., Davies, J., Parnell, A., Moreland, P., Stach, J. E. M., Van der Kamp, M., Willis, C. & Race, P., 18 Feb 2019, In: Angewandte Chemie - International Edition. 58, 8, p. 2305-2309 5 p.

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  • Esterases
  • Biosynthesis
  • Lyases
  • Acetates
  • Enzymes
  3 Citations (Scopus)

  124 Downloads (Pure)

• Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs

  Li, H., Valkenier, H., Thorne, A., Dias, C. M., Cooper, J. A., Keiffer, M., Busschaert, N., Gale, P. A., Sheppard, D. N. & Davis, A. P., 2 Oct 2019, In: Chemical Science. 10, 42, p. 9663-9672 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Drug Delivery Systems
  • Anions
  • Bioactivity
  • ivacaftor drug combination lumacaftor
  • Toxicity
  17 Citations (Scopus)

  182 Downloads (Pure)

• A Photoresponsive Stiff-Stilbene Ligand Fuels the Reversible Unfolding of G-Quadruplex DNA

  O'Hagan, M., Haldar, S., Duchi, M., Oliver, T. A. A., Mulholland, A., Morales, J. C. & Galan, C., 22 Mar 2019, In: Angewandte Chemie - International Edition. 58, 13, p. 4334-4338 5 p.

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  • Stilbenes
  • Ligands
  • DNA
  • Photooxidation
  • Oligonucleotides
  18 Citations (Scopus)

  68 Downloads (Pure)

• A Rapid Synthetic Approach to the ABCD Core of the Stemona Alkaloids

  Connelly, R., Knowles, J. & Booker-Milburn, K., 4 Jan 2019, In: Organic Letters. 21, 1, p. 18-21 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • Stemonaceae
  • alkaloids
  • Alkaloids
  • Lewis Acids
  • acids
  5 Citations (Scopus)

  104 Downloads (Pure)

• Binding and beyond: what else can G-quadruplex ligands do?

  O'Hagan, M., Morales, J. & Galan, C., 5 Jul 2019, In: European Journal of Organic Chemistry. 24 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

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  • ligands
  • Ligands
  • nucleic acids
  • Nucleic Acids
  • Functional materials
  17 Citations (Scopus)

  73 Downloads (Pure)

• Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium‐Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides

  Dalling, A., Yamauchi, T., McCreanor, N., Cox, L. & Bower, J., 2 Jan 2019, In: Angewandte Chemie - International Edition. 58, 1, p. 221-225 5 p.

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  • Cyclopropanes
  • Cycloaddition
  • Electrons
  • Chemical activation
  • Alkenes
  15 Citations (Scopus)

  173 Downloads (Pure)

• Computational mapping of redox-switchable metal complexes based on ferrocene derivatives

  Lai, A., Clifton, J., Diaconescu, P. L. & Fey, N., 21 Jun 2019, In: Chemical Communications. 55, 49, p. 7021-7024 4 p.

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  • ferrocene
  • Metal complexes
  • Coordination Complexes
  • Oxidation-Reduction
  • Ring opening polymerization
  6 Citations (Scopus)

  43 Downloads (Pure)