Research Outputs
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Search results
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Altered Gene Expression Within the Renin–Angiotensin System in Normal Aging and Dementia
Tayler, H. M., Maclachlan, R., Güzel, Ö., Fisher, R. A., Skrobot, O. A., Abulfadl, M. A., Kehoe, P. G. & Miners, J. S., 1 Jan 2024, In: Journals of Gerontology, Series A. 79, 1, 10 p., glad241.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease
Van Hulle, C., Ince, S., Okonkwo, O. C., Bendlin, B. B., Johnson, S. C., Carlsson, C. M., Asthana, S., Love, S., Blennow, K., Zetterberg, H. & Miners, J. S., 5 Jan 2024, (E-pub ahead of print) In: Translational Psychiatry. 14, 1, 8 p., 3.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access11 Citations (Scopus) -
Neuroinflammation in Comorbid Depression in Alzheimer’s Disease: a pilot study using post-mortem brain tissue.
Lin, J., Morisaki, M., Sampathkumar, S., Lau, L., Boche, D., Khandaker, G. & Sinclair, L. I., 3 Mar 2024, (E-pub ahead of print) In: Neuroscience Applied.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer's disease pathology in mouse models of Alzheimer's disease
Maclachlan, R. A., Evans, C., Chai, S., Good, M., Kehoe, P. G. & Miners, J. S., 1 Jan 2023, In: Aging Brain. 3, 100062.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Citations (Scopus)83 Downloads (Pure) -
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (Nature Communications, (2021), 12, 1, (3417), 10.1038/s41467-021-22491-8)
EADB contributors & Ruiz, A., 9 Feb 2023, In: Nature Communications. 14, 1, p. 716 716.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Characterization of Depressive Symptoms in Dementia and Examination of Possible Risk Factors
Sinclair, L. I., Lawton, M. A., Palmer, J. C. & Ballard, C., 7 Mar 2023, In: Journal of Alzheimer's Disease. 7, 1, p. 213-225 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus) -
Does depression in mid-life predispose to greater cognitive decline in later life in the Whitehall II cohort?
Sinclair, L. I., Ball, H. A. & Bolea-Alamanac, B. M. B. M., 15 Aug 2023, In: Journal of Affective Disorders. 335, p. 111-119 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage
Tayler, H. M., MacLachlan, R., Güzel, Ö., Miners, J. S. & Love, S., 4 Apr 2023, In: Brain Communications. 5, 2, fcad112.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access8 Citations (Scopus) -
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration, 17 May 2023, In: JAMA Network Open. 6, 5, p. e2313734 e13734.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access55 Citations (Scopus) -
Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study
Dominantly Inherited Alzheimer Network (DIAN), Xu, Y., Aung, H. L., Bateman, R. J., Brooks, W. S., Chhatwal, J., Day, G. S., Fagan, A. M., Farlow, M. R., Gordon, B., Kehoe, P. G., Levin, J., Mori, H., Morris, J. C., Wharton, W., Humburg, P., Schofield, P. R. & Peters, R., 15 Nov 2023, In: Alzheimer's and Dementia. 19, 11, p. 4999-5009 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
Is later-life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post-mortem human brain tissue?
Sinclair, L. I., Mohr, A., Morisaki, M., Edmondson, M., Chan, S., Bone-Connaughton, A., Turecki, G. & Love, S., 12 Sept 2023, (E-pub ahead of print) In: Alzheimer's Research and Therapy. 15, 15 p., 153.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access10 Citations (Scopus) -
SARS-CoV-2 targets pericytes to restrict blood flow within the brain
Miners, J. S., Fisher, R. A. & Love, S., 1 Feb 2023, In: Brain. 146, 2, p. 418-420 3 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)52 Downloads (Pure) -
The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint
Jönsson, L., Wimo, A., Handels, R., Johansson, G., Boada, M., Engelborghs, S., Frölich, L., Jessen, F., Kehoe, P. G., Kramberger, M., de Mendonςa, A., Ousset, P. J., Scarmeas, N., Visser, P. J., Waldemar, G. & Winblad, B., Jun 2023, In: The Lancet Regional Health - Europe. 29, p. 100657 100657.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open Access74 Citations (Scopus) -
APOE ε4, Alzheimer's disease neuropathology, and sleep disturbance, in individuals with and without dementia
Blackman, J., Love, S., Sinclair, L. I., Cain, R. J. & Coulthard, E. J., 30 Mar 2022, In: Alzheimer's Research and Therapy. 14, 1, 11 p., 47 .Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile20 Citations (Scopus)77 Downloads (Pure) -
Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
Members of the EADB, GR@ACE, DEGESCO, DemGene, GERAD, and EADI Groups, 1 Jul 2022, In: JAMA Neurology. 79, 7, p. 652-663 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile55 Citations (Scopus)28 Downloads (Pure) -
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
European Alzheimer & Dementia BioBank (EADB), 4 Feb 2022, In: Alzheimer's Research & Therapy. 14, 1, 22.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile8 Citations (Scopus)29 Downloads (Pure) -
Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential
Shao, X., Vishweswaraiah, S., Čuperlović-Culf, M., Yilmaz, A., Greenwood, C. M. T., Surendra, A., McGuinness, B., Passmore, P., Kehoe, P. G., Maddens, M. E., Bennett, S. A. L., Green, B. D., Radhakrishna, U. & Graham, S. F., 22 Nov 2022, In: Communications Biology. 5, 1, p. 1279Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
Shireby, G., Dempster, E. L., Policicchio, S., Smith, R. G., Pishva, E., Chioza, B., Davies, J. P., Burrage, J., Lunnon, K., Seiler Vellame, D., Love, S., Thomas, A., Brookes, K., Morgan, K., Francis, P., Hannon, E. & Mill, J., 24 Sept 2022, In: Nature Communications. 13, 1, p. 5620 5620.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access54 Citations (Scopus) -
Dysregulation of ACE-1 in Normal Aging and the Early Stages of Alzheimer's Disease
MacLachlan, R., Kehoe, P. G. & Miners, J. S., 9 Apr 2022, In: Journals of Gerontology, Series A. 77, 9, p. 1775-1783 9 p., glac083.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Citations (Scopus)70 Downloads (Pure) -
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
Pihlstrøm, L., Shireby, G., Geut, H., Henriksen, S. P., Rozemuller, A. J. M., Tunold, J.-A., Hannon, E., Francis, P., Thomas, A. J., Love, S., Mill, J., van de Berg, W. D. J. & Toft, M., 22 Aug 2022, In: Nature Communications. 13, 1, 10 p., 4932.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile22 Citations (Scopus)33 Downloads (Pure) -
High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer’s and Parkinson’s disease
Emery, D. C., Davies, M., Cerajewska, T. L., Taylor, J., Hazell, M., Paterson, A. R., Allen-Birt, S. J. A. & West, N. X., 9 Dec 2022, In: Frontiers in Aging Neuroscience. 14, 25 p., 1026260.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Citations (Scopus)91 Downloads (Pure) -
Iron Deposition in the Brain After Aneurysmal Subarachnoid Hemorrhage
Galea, I., Durnford, A., Glazier, J., Mitchell, S., Kohli, S., Foulkes, L., Norman, J., Darekar, A., Love, S., Bulters, D. O., Nicoll, J. A. R. & Boche, D., 24 Feb 2022, (E-pub ahead of print) In: Stroke. 53, 5, p. 1633-1642 10 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
41 Citations (Scopus) -
Late-life blood pressure and markers of vascular and disease pathology in Alzheimer’s, vascular, and mixed dementia
Tayler, H. M., Guzel, O., MacLachlan, R. A., Miners, J. S. & Love, S., 9 Jun 2022, (Unpublished).Research output: Contribution to conference › Conference Poster › peer-review
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New insights into the genetic etiology of Alzheimer's disease and related dementias
EADB, 4 Apr 2022, In: Nature Genetics. 54, 4, p. 412-436 25 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1139 Citations (Scopus)63 Downloads (Pure) -
Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives
Fisher, R. A., Miners, J. S. & Love, S., 28 Oct 2022, In: Brain Pathology. 32, 6, e13061.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile69 Citations (Scopus)298 Downloads (Pure)